Abstract: Objective To afford experimental basis for establishing the standard biological properties' datum of APPswe/PS1dE9 transgenic mice model on Alzheimer's disease. Methods The heterozygote of the APP/PS1 transgenic mice were used to breed, and the identify method of genotype was established. The reproductive performance and growth of different litters and genotype were analysed within four litters of 1158 mice in 160 litters. Results ① The section of APP/PS1 was 600 bp. ② The quantity of the newborn mice and transgenic positive in litter 2 and 3-were more than litter 1(P<0.05), but the positive rate had no significant difference(P>0.05). ③ The birth interval between parity 1 and 2 was shorter than other's (P<0.05). Litter size, number of mice weaned and survival rate after weaning of the parity 2 and 3 were higher than other two (P<0.05). ④ The litter weight at birth, lactescence, body weight after weaning of parity 3 and 4 were stable. ⑤ The highest weight of female and male APP/PS1 transgenic mice are 24.45±0.92 g and 30.21±2.53 g separately. ⑥ This transgenic mouse genotype did not affect its weight. Conclusions The basic biological characteristics data of APP/PS1 transgenic mouse are established, and provide the exact data for scientific research.

Key words: Alzheimer's disease, APP/PS1 transgenic mice, Reproductive performance, Growth