Comparative Studies on Behavior of C57BL/6J、129/SvJ and Their Hybrid Mice

doi:10.3969/j.issn.1674-5817.2019.06.002

Abstract

Abstract: Objective To compare the genetic backgrounds of C57BL/6J and 129/SvJ and the behavioral phenotypes with their hybrid (F1) mice. Methods C57BL/6J and 129/SvJ were cross mated and bred to obtain two F1 (129B6F1 and B6129F1). These F1 mice with C57BL/6J and 129/SvJ were divided into 8 groups of experimental mice according to different gender. Numbers of mice in each group were no less than 12. Behavioral studies such as the open field test, the tail suspension test, the morris water maze, the passive avoidance test, the hot plate were conducted to compare the behavioral performance of C57BL/6J, 129/SvJ and F1 from the paramters of anxiety, depression, learning and memory, and heat pain response respectively. Results Compared with 129/SvJ, F1 had significant difference in peripheral and marginal activities in the open field activities (P<0.01). There was no significant difference in the behavior of F1 and parent mice in the tail suspension activities. Compared with C57BL/6J, the latency of finding the platform and entering the dark box of F1 were significantly different in the morris water maze and the passive avoidance activities (P<0.05). Conclusion Different behavior phenotypes of F1 are influenced by different genetic backgrounds of their parents.

Key words: Inbred mice, C57BL/6J, 129/SvJ, Hybrid (F1), Behavior

CLC Number:

Q95-33

WAN Ying-han, SHEN Rui-ling, WANG Jue, GONG Hui, LI Jun, DONG Ru, FEI Jian. Comparative Studies on Behavior of C57BL/6J、129/SvJ and Their Hybrid Mice[J]. Laboratory Animal and Comparative Medicine, 2019, 39(6): 429-436.

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