An Modified Eight-arm Maze Experiment Method in Behavioral Research

doi:10.3969/j.issn.1674-5817.2019.03.009

Abstract

Abstract: Objective To identify a simple and effective experimental method for eight-arm maze study. Methods Twenty adult male SD rats were divided into a traditional method group (control group) and a modified electric heating pad method group (test group) (n=10). The bait was only placed at the end of feeding arm in control group. The test group had the same conditions as control group except that the heating pad was placed at the end of the non-predator arm as a punishment tool. Recorded and compared the moving distance, time, speed and the entrance times of rat in the arms via software. Results Compared with the control group, the test group rats shortened the movement distance and explored time significantly, and reduced the errors times into the wrong arm significantly as well. Conclusion Compared with the traditional method, the modified electric heating pad method can evaluate the spatial memory learning ability of rats after 7-days-training more accurately and effectively, which can be used as an effective experimental method.

Key words: Eight-arm maze, Spatial learning and memory, Behavior, Animal experiment

CLC Number:

Q95-33

LIU Bo, WANG Yang, LI Zhi-jie. An Modified Eight-arm Maze Experiment Method in Behavioral Research[J]. Laboratory Animal and Comparative Medicine, 2019, 39(3): 226-230.

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