Research Progress of Animal Model Establishment and Gene Editing on Plasmodium falciparum

doi:10.3969/j.issn.1674-5817.2019.01.013

Abstract

Abstract: Plasmodium falciparum is the pathogen of human malaria. The animal model of plasmodium falciparum is an important experimental tool to study the infection process of plasmodium falciparum, the mechanism of chronic pathogenesis, the evaluation of drugs and the vaccine on plasmodium falciparum. Up to now, the animal model research of plasmodium falciparum mainly involves non-human primates, immuno-deficient mice, transgenic technology and CRISPRR/Cas9 system. In this paper, the animal model of plasmodium falciparum in vitro/vivo infection and gene editing were summarized and analyzed to provide reference for the establishment of animal model and gene editing of plasmodium falciparum in the future.

Key words: Plasmodium falciparum, in vitro infection, in vivo infection, Gene editing

CLC Number:

Q95-33

KUANG De-xuan, WANG Wen-guang, SUN Xiao-mei, DAI Jie-jie. Research Progress of Animal Model Establishment and Gene Editing on Plasmodium falciparum[J]. Laboratory Animal and Comparative Medicine, 2019, 39(1): 65-71.

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