Study on Indicators of Chronic Fatigue Syndrome Model in Rat

doi:10.3969/j.issn.1674-5817.2018.04.007

Abstract

Abstract: Objective To make a rat model of chronic fatigue syndrome (CFS) by overcrowding and other stresses,and to test the related indicators.Methods The rats were stimulated by different stress factors,such as irregular crowding,noise and diurnal reversal for 64 days.The mental status,coat and skin color were observed.Weight and food intake were measured every week.Blood routine,immunoglobulin G (IgG) and blood lactate were measured regularly.Results After modeling,rat independent activity decreased.Mental fatigue,skin loosed,body hair withered,and semi-quantitative score value increased.Body weight and food intake decreased.White blood cell,red blood cell,hemoglobin and erythrocyte specific volume decreased.Inactive time after forced swimming,blood lactic acid and IgG increased.Conclusion The rat models of CFS were successfully constructed by overcrowding,noise and sleep disorders.Semi-quantitative scores,body weight,food intake,white blood cell,red blood cell,hemoglobin,erythrocyte specific volume,inactive time after forced swimming,blood lactic acid and IgG can be used as reference indicators.

Key words: Chronic fatigue syndrome (CFS), Indicators, Rat

CLC Number:

R33Q95-33

RAO Zi-liang, FENG Xue-xuan, HUANG Xiao-hong, LI Li-si, LI Jin-feng, KUANG Shao-song, WANG Gang. Study on Indicators of Chronic Fatigue Syndrome Model in Rat[J]. Laboratory Animal and Comparative Medicine, 2018, 38(4): 278-283.

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