The Effect of Sleep Deprivation on Growth and Development in Mice

doi:10.3969/j.issn.1674-5817.2018.03.009

Abstract

Abstract: Objective Detection on weight,blood parameters,hormone levels,and immune levels after sleep deprivation was conducted,to examine the impact of sleep deprivation on adolescents’various systems and growth.Methods A mouse model of chronic sleep deprivation was constructed using a platform-based sleep deprivation device for 20 days.During the period,normal daily routine mice were used as controls.The weight,hematological parameters,serum corticosterone,growth hormone,interleukin-2,and spleen corticosterone receptor levels.of mice in the sleep deprivation group were detected.And bone mass was measured using MicroCT,too.Results The body weight,hematological parameters of mice corticosterone,growth hormone,interleukin-2,and spleen corticosterone receptor levels in the sleep deprivation group were lower than controls’s.MicroCT test found that bone mass was significantly worse in the sleep deprived group than the control group.Conclusion Studies have shown that lack of sleep affects the normal growth and development of the main organs and body systems,which can potentially damage the overall immune function and nervous system function of mice.This result suggests that sleep plays an important role in the growth and development of adolescents.

Key words: Sleep, Neuroendocrine, Immunity, Bone

CLC Number:

Q95-33

ZHANG Ya-quan, YANG Wen-jing, LIN Li-fang, RUAN Wen-jie. The Effect of Sleep Deprivation on Growth and Development in Mice[J]. Laboratory Animal and Comparative Medicine, 2018, 38(3): 212-216.

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