Abstract: Objective To explore the difference of peripheral nerve regeneration between C57BL/6 mice and B6-St mice (short tail mice) comparing sciatic nerve injury mice model.Methods Healthy C57BL/6 mice and B6-St mice were selected for study.Each group was half the male and female.All the mice were treated with left sciatic nerve injury to induce the model mice which were followed up for 8,12 and 16 days after surgery to calculate the sciatic function index (SFI).All mice were subjected to electrophysiological examination 21 days after the operation.The composite muscle motion potentials (CMAPs) were recorded.The bilateral gastrocnemius muscle of each group was used to calculate the wet weight ratio of gastrocnemius muscle.The frozen gastrectomy was performed on the gastrocnemius muscle.The cross-sectional area (CSA) of the muscle fibers was measured by HE staining.Results The SFI values of the two groups were not significantly different on 8,12 and 16 days after operation (P>0.05).There was no significant difference in the composite muscle between the two groups (P>0.05).There was no significant difference between the two groups in terms of the wet weight of the gastrocnemius muscle.There was no significant difference in the CSA between the two groups.Conclusion The peripheral nerve regeneration ability of B6-St mice is similar to that of C57BL/6 mice.

Key words: B6-St mice, Peripheral nerve regeneration, Sciatic function index (SFI), Compound muscle action potentials (CMAPs)