Laboratory Animal and Comparative Medicine ›› 2019, Vol. 39 ›› Issue (4): 310-313.DOI: 10.3969/j.issn.1674-5817.2019.04.010

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Anesthetic Effect Evaluation of Combined Zoletil 50 with Dexdomitor in BALB/c Mouse

ZOU Lu1,2, DAI Tian-e3, LU Xiao2, AI Xiao-jie1   

  1. 1. School of Agriculture and Biology/Shanghai Key Laboratory of Veterinary Biotechnology,Shanghai Jiao Tong University, Shanghai 200240,China;
    2. Dizal Shanghai Pharmaceutical Co., Ltd., Shanghai 201203, China;
    3. Prisys Biotechnologies Co., Ltd., Shanghai 201203, China
  • Received:2019-02-20 Online:2019-08-25 Published:2021-01-31

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Abstract: Objective To evaluate the anesthetic effect of combined Tiletamine/Zolazepam (Zoletil 50) with Dexmedetomidine (Dexdomitor) in BALB/c mouse. Methods Nine male and 9 female BALB/c mice were randomly divided into 2 groups. A group mice were assigned to Zoletil 50 and Dexdomitor. B group mice were assigned to same dosage, 1 hour after stable anesthesia, added with Antipamezole (Antisedan). Results The anesthetic effect of combined Zoletil 50with Dexdomitor present well in BALB/c mouse. The recovery time of group B was shorter than group A (P<0.05). Conclusion Combined Zoletil 50 with Dexdomitor is an excellent anesthetic method for BALB/c mouse.

Key words: Anesthesia, Tiletamine/Zolazepam (Zoletil 50), Dexmedetomidine (Dexdomitor), Antipamezole (Antisedan), BALB/c mouse

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