Advances in Research on Relationship between Transporter Associate with Antigen Processing Gene Polymorphism and Diseases

doi:10.3969/j.issn.1674-5817.2017.03.017

Abstract

Abstract: Transporter associate with antigen processing (TAP) is a heterodimer which plays a crucial role in antigen presenting process by transporting endogenous antigen peptide from the cytoplasm to the endoplasmic reticulum where can be bound by the major histocompatibility complex (MHC) class I molecules and further be recognized by CD8+T lymphocyte. Polymorphisms of TAP gene and the expression level of TAP protein are associated with susceptibility to certain specific diseases including tumor, autoimmune disease, viral disease and infectious diseases. Here, some similar comparative medicine researches of TAPs in laboratory animals to diseases associations are reviewed.

Key words: Transporter associate with antigen processing (TAP), Polymorphism, Diseases, Association

CLC Number:

Q95-33

WANG Xing-tong, CHEN Hong-yan, HAN Ling-xia. Advances in Research on Relationship between Transporter Associate with Antigen Processing Gene Polymorphism and Diseases[J]. Laboratory Animal and Comparative Medicine, 2017, 37(3): 252-256.

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