A Comparison on Hyperlipidemia Rat Models Induced by High-fat Diet with Different Proportions of Sugar and Oil

doi:10.3969/j.issn.1674-5817.2017.03.007

Abstract

Abstract: Objective To compare hyperlipidemia rat models induced by high-fat diet with different proportions of sugar and oil. Methods Fourty rats were divided into normal control group and three high-fat diet (I, II and III) groups with 10 rats per each. The normal control group was fed with normal diet, and the other three groups were fed with high-fat diet with different proportions of sugar and oil for 6 weeks respectively. The body weight and the total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in serum were detected weekly. Results No significant difference were observed on body weight among different groups. The TC, LDL-C and TC/HDL-C ratios in all high-fat diet groups were higher than those of normal control group at each time point. The TG in high-fat diet II group was higher than normal control group at each time point, but was only higher at the first 4 weeks in high-fat diet I group, and no significant difference in high-fat diet III group except at second week. Conclusion Both high-fat diet I and II can induce combined hyperlipidemia rat models rapidly and steady, and high-fat diet II is more superior. High-fat diet III may be applied to induce hypercholesterolemia in rat.

Key words: High-fat diet, Sugar and oil, Hyperlipidemia, Rat

CLC Number:

Q95-33

QIN Hui-yan, WANG Shao-long, WEN Ping-jing, ZHAO Peng, LI Bin, ZHANG Jie-hong. A Comparison on Hyperlipidemia Rat Models Induced by High-fat Diet with Different Proportions of Sugar and Oil[J]. Laboratory Animal and Comparative Medicine, 2017, 37(3): 209-213.

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