Establishment of Highland Multiple Organ Dysfunction Syndrome Model in Juema Minipig and Changes of Adrenocorticotropic Hormone and Corticosterone

doi:10.3969/j.issn.1674-5817.2016.02.005

Abstract

Abstract: Objective To study the expression changes of adrenocorticotropic hormone (ACTH) and corticosterone (CORT) by model of the highland multiple organ dysfunction syndrome (H-MODS) in Juema minipig. Methods The H-MODS model was induced by different dosages of lipopolysaccharide (LPS) in Juema minpig (groups B, C and D), the saline as the control. The expression of CORT and ACTH in serum at different times were detected. Results The expression of ACTH in model groups were rised after pumping LPS and reduce after 12 h, and to return the same as the control in the 72 h. The expression of CORT was rised to highest at 3 h after pumping LPS and then to decline, but to rise after 24 h, and to return the same as the control in the 72 h. The changes in groups of B, C and D have the same trendency. Conclusion The H-MODS has the severe infection in the model minipigs, the expression of CORT and ACTH have significient changes, and the regulation balance of hypothalamic-pituitary-adrenal axis was broken.

Key words: Highland multiple organ dysfunction syndrome(H-MODS), Juema minipig, Adrenocorticotropic hormone (ACTH), Corticosterone (CORT)

CLC Number:

Q95-33

FENG Xiao-ming, LUO Xiao-hong, WANG Hong-yi, GUO Xiao-yu, LU Lu, SHEN Jian, XIAO Pan, NIU Ting-xian. Establishment of Highland Multiple Organ Dysfunction Syndrome Model in Juema Minipig and Changes of Adrenocorticotropic Hormone and Corticosterone[J]. Laboratory Animal and Comparative Medicine, 2016, 36(2): 107-112.

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