Nephrotoxicity of EDTA Utilized to Treat Chronic Cadmium Poisoning in Rats and Mice

doi:10.3969/j.issn.1674-5817.2015.01.012

Abstract

Abstract: Objective To investigate the side effects of (EDTA) utilized to treat chronic Cadmium poisoning in animals. Methods Male SD rats and NIH mice were randomly divided to the control group and model group respectively. The model group animals were daily given CdCl₂+ 2-Mercaptoethanol(ME, ip) for 5 days. 50 days or 30 days later, the rats or mice were randomly divided into model control group and EDTA treatment group respectively. The control group and model control group were injected with saline, and the EDTA group animals were treated with EDTA solution .At the end of the experiment, the urine, blood, kidneys and testis were collected for detecting the Cd concentration and pathologic changes. Results Compared with the model control group, in the EDTA treated groups (both in rats and mice), the Cd levels of kidney, urine and blood all increased significantly (P<0.05); protein precipitation could be detected in kidney tubules. Conclusion The EDTA could promote the accumulation of cadmium in the kidney. EDTA is not recommended to treat chronic cadmium poisoning patients.

Key words: Chronic cadmium poisoning, EDTA, Nephrotoxicity

CLC Number:

Q95-33

LI Guang-xian, ZHONG Zhi-yong, CHEN Jia-xing, YU Ri-an, TANG Xiao-jiang. Nephrotoxicity of EDTA Utilized to Treat Chronic Cadmium Poisoning in Rats and Mice[J]. Laboratory Animal and Comparative Medicine, 2015, 35(1): 56-60.

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