Comparison of SNP and STR Genotypes in Chromosome 1 Substitution Strains

doi:10.3969/j.issn.1674-5817.2012.05.005

Abstract

Abstract: Objective To compare the genotyping results of STR and SNP and choose typing methods for three chromosome 1 substitution strains. Methods The three chromosome 1 substitution strains included 40 samples were typed respectively by 20 SNP and 10 STR. Results A total of 6 samples, 9 samples, 4 samples were identified respectively with SNP among 40 samples of C3H/He, FVB/N and AKR chromosome substitution strains. A total of 6 samples, 10 samples, 6 samples were identified respectively with STR among the 40 samples of C3H/He, FVB/N and AKR chromosome substitution strains. Conclusion For each strain with different gene background,. 3 groups of STR on chromosome 1 were chosen as genotyping methods of C3H/He chromosome 1 substitution strain. 3 groups of SNP were chosen as genotyping methods of FVB/N and AKR chromosome 1 substitution strains.

Key words: Chromosome 1 substitution strains, STR, SNP, Typing, Comparison

CLC Number:

Q95-33

ZHAO Li-ya, ZHAO Ying, CHAO Tian-zhu, LIU Lei, XING Zheng-hong, CHEN Guo-qiang, XIAO Jun-hua. Comparison of SNP and STR Genotypes in Chromosome 1 Substitution Strains[J]. Laboratory Animal and Comparative Medicine, 2012, 32(5): 396-400.

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