Discussion on the Construction Experience of Laboratory Animal Facilities in Universities and Research Institutes

doi:10.12300/j.issn.1674-5817.2022.042

Abstract

Abstract:

Laboratory animal facilities, as the main place for animal raising and experiment, have strict requirements on environmental conditions such as temperature, humidity, pressure, noise, air cleanliness class and ventilation rate. Laboratory animal facilities also have standardized management requirements for personnel operation, goods and animals entering and leaving the facilities. Based on the construction and management experience of laboratory animal facilities in Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences in the past 10 years (2012-2022), we summarized and discussed the experience from design planning to equipment selection, aiming to provide practical reference of the construction of experimental animal facilities to universities and research institutes.

Key words: Animal facility, Construction, Management, Practice

CLC Number:

Q95-33

Huiran LIN, Zhaoxia LIU, Xiaobiao FENG, Minjie LIU, Xiaojie HUANG. Discussion on the Construction Experience of Laboratory Animal Facilities in Universities and Research Institutes[J]. Laboratory Animal and Comparative Medicine, 2022, 42(5): 453-457.

Figures/Tables 1

References 14

1	中华人民共和国国家质量监督检验检疫总局, 中国国家标准化管理委员会. 实验动物环境及设施: [S]. 北京: 中国标准出版社, 2010.
	General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China; China National Standardization Administration. Laboratory Animal—Requirements of environment and housing facilities: [S].Beijing: China Standards Press, 2010.
2	中华人民共和国住房和城乡建设部. 实验动物设施建筑技术规范: [S]. 北京: 中国标准出版社, 2008.
	Ministry of Housing and Urban Rural Development of the People's Republic of China. Architectural and technical code for laboratory animal facilities: [S]. Beijing: China Standards Press, 2008.
3	袁进, 吴清洪, 田雨光, 等. 科研动物实验室建设体会及管理模式探讨[J]. 实验室科学, 2021, 24(6):147-152.
	YUAN J, WU Q H, TIAN Y G, et al. Discussion on the construction and management mode of scientific research animal laboratory in medical colleges and universities[J]. Lab Sci, 2021, 24(6):147-152.
4	于承志, 倪训松, 费根林. 实验动物屏障环境节能设计方案探讨[J]. 实验动物科学, 2012, 29(4):40-43. DOI:10.3969/j.issn.1006-6179.2012.04.010 .
	YU C Z, NI X S, FEI G L. Discussion on energy-saving design of laboratory animal barrier environment[J]. Lab Animal Sci, 2012, 29(4):40-43. DOI:10.3969/j.issn.1006-6179.2012.04.010 .
5	刘静, 孙文彤, 邢云梁. 某高层实验动物设施机房设置优化及节能设计[J]. 暖通空调, 2021, 51(S2):152-156.
	LIU J, SUN W T, XING Y L. Optimization and energy-saving design of computer room in a high-rise laboratory animal facility[J]. Heat Vent ＆ Air Cond, 2021, 51(S2):152-156.
6	王文涛, 郑功杭, 李先庭, 等. 利用室内空气循环净化降低实验动物房新风量的节能效果[J]. 制冷学报, 2021, 42(6):1-7. DOI:10.3969/j.issn.0253-4339.2021.06.001 .
	WANG W T, ZHENG G H, LI X T, et al. Energy-saving effect of air-conditioning system in laboratory animal room with less fresh air volume and purification of indoor circulating air[J]. J Refrig, 2021, 42(6):1-7. DOI:10.3969/j.issn.0253-4339.2021.06.001 .
7	龚光彩, 贺习之, 陈盟君, 等. 屏障环境中IVC小鼠饲养微环境控制方法研究[J/OL]. 制冷学报, 2022-06-02. .
	GONG G C, HE X Z, CHEN M J, et al. Research on the control method of feeding microenvironment of individually venti-lated mouse cages in barrier environment[J/OL]. Journal of Refrigeration, 2022-06-02..
8	ZYNDA J R. A shift in designing cage-washing operations[J]. Lab Animal, 2015, 44(4):146-149. DOI:10.1038/laban.663 .
9	张婷, 陈亮亮, 李海翔, 等. 溶液式环境控制设备在实验动物设施中的应用[J]. 实验动物与比较医学, 2021, 41(2):161-165. DOI:10.12300/j.issn.1674-5817.2020.199 .
	ZHANG T, CHEN L L, LI H X, et al. Application of liquid desiccant environmental control equipment in laboratory animal facilities[J]. Lab Animal Comp Med, 2021, 41(2):161-165. DOI:10.12300/j.issn.1674-5817.2020.199 .
10	CASTELHANO-CARLOS M J, BAUMANS V. The impact of light, noise, cage cleaning and in-house transport on welfare and stress of laboratory rats[J]. Lab Anim, 2009, 43(4):311-327. DOI:10.1258/la.2009.0080098 .
11	STAKUTIS R E. Cage rack ventilation options for laboratory animal facilities[J]. Lab Animal, 2003, 32(8):47-52. DOI:10.1038/laban0903-47 .
12	衣启营, 张凤梅, 高杰, 等. 屏障系统内实验动物饮水4种处理方式的菌落监测比较观察[J]. 医学动物防制, 2017, 33(11):1169-1171. DOI:10.7629/yxdwfz201711015 .
	YI Q Y, ZHANG F M, GAO J, et al. Comparative observations on the colonies monitoring of four different drinking water treatment for the laboratory animals in barrier system[J]. J Med Pest Control, 2017, 33(11):1169-1171. DOI:10.7629/yxdwfz201711015 .
13	郑艳茹, 李臣亮, 王彦峰, 等. 实验动物室可自动饮水式IVC独立通风鼠笼的开发与应用[J]. 中国现代教育装备, 2021(7):59-61. DOI:10.13492/j.cnki.cmee.2021.07.019 .
	ZHENG Y R, LI C L, Wang F F, et al. Development and application of IVC independent ventilation cage with automatic drinking water in laboratory animal room[J]. China Mod Educ Equip, 2021(7):59-61. DOI:10.13492/j.cnki.cmee.2021.07.019 .
14	刁瑞国, 张文明, 李娜. 实验动物设施废气处理设备工艺选择[J]. 实验动物科学, 2021, 38(1):53-55. DOI:10.3969/j.issn.1006-6179.2021.01.010 .
	DIAO R G, ZHANG W M, LI N. Technological process of waste gas treatment equipment for laboratory animal facilities[J]. Lab Animal Sci, 2021, 38(1):53-55. DOI:10.3969/j.issn.1006-6179.2021.01.010 .

[1]	Yishu LIU, Shanmin ZHAO, Liping CAI. Application and Comparison of Different Anesthetic Ventilation Methods in Minimally Invasive Thoracic Surgery Training [J]. Laboratory Animal and Comparative Medicine, 2024, 44(1): 97-104.
[2]	Zhengwen MA, Xiaying LI, Xiaoyu LIU, Yao LI, Jian WANG, Jin LU, Guoyuan CHEN, Xiao LU, Yu BAI, Xuancheng LU, Yonggang LIU, Wanyong PANG, Yufeng TAO. Interpretation and Elaboration for the ARRIVE Guidelines 2.0—Animal Research: Reporting In Vivo Experiments (V) [J]. Laboratory Animal and Comparative Medicine, 2024, 44(1): 105-114.
[3]	Qianqian TANG, Xiuli ZHANG, Zai CHANG. Statistical Analysis of the Leakage Situation in the Automated Watering System for Mice in Tsinghua University Laboratory Animal Resources Center [J]. Laboratory Animal and Comparative Medicine, 2024, 44(1): 85-91.
[4]	Huan GOU, Xinying AN, Yujia TONG, Yan WANG, Shuang YANG. Analysis on the Development Status of Laboratory Animals in Japan [J]. Laboratory Animal and Comparative Medicine, 2023, 43(2): 194-204.
[5]	Chongyang QI, Lin CHEN, Man AI, Hang XU, Housen ZHANG. Safety Management Countermeasures Based on the Status of Laboratory Animal Administrative Licensing in Jiangsu Province [J]. Laboratory Animal and Comparative Medicine, 2023, 43(1): 79-85.
[6]	Haibo YU, Jie ZHOU, Jianhong LI, Changwen LI, Caixia Gao, Changyou XIA. Establishment and Interpretation of Group Standard for Laboratory Animal—Guideline for the Welfare of SPF Chicken [J]. Laboratory Animal and Comparative Medicine, 2022, 42(6): 572-576.
[7]	Huiping LI, Chujun LIANG, Weibo ZHAO. The Current Status of Laboratory Animal License Administration in Guangdong Province [J]. Laboratory Animal and Comparative Medicine, 2022, 42(6): 577-582.
[8]	Lei WANG, Hufeng XU. Application of the Wechat Booking Platform in Reservation System of the Operating Room in Laboratory Animal Center of Beijing Friendship Hospital [J]. Laboratory Animal and Comparative Medicine, 2022, 42(5): 448-452.
[9]	Qi REN, Yandong LI, Qiang SUN. Preliminary Study on Raising and Maintaining Clean Mice with Micro-barrier Cages in Conventional Environmental Facilities [J]. Laboratory Animal and Comparative Medicine, 2022, 42(5): 440-447.
[10]	Xiuqing ZHENG, Zhiqiang SHAO, Jing SONG, Yuehua ZHANG, Jinhua SU. Practice of ABSL-2 Laboratory Process Management in Universities： Xiamen University as An Example [J]. Laboratory Animal and Comparative Medicine, 2022, 42(4): 364-370.
[11]	Haiyu LI, Hufeng XU. Discussion on the Problems and Methods of Animal Laboratory Documents Management from the Perspective of Audit [J]. Laboratory Animal and Comparative Medicine, 2022, 42(3): 244-247.
[12]	Yong LI, Liang ZHOU, Yong HE, Zhifeng YAN, Haijiang WANG. Preliminary Exploration of Information Supervison System for Harmless Disposal of Laboratory Animal Carcasses and Related Wastes [J]. Laboratory Animal and Comparative Medicine, 2022, 42(2): 122-126.
[13]	Yuqin YANG. Biosafety Problems and Countermeasures in the Management of Barrier Facilities for Laboratory Animals [J]. Laboratory Animal and Comparative Medicine, 2022, 42(2): 95-101.
[14]	LUO Yinzhu, Min Fangui, WANG Jing, HE Lifang, PAN Jinchun. Prevention and Control of Pathogenic Microorganisms for the Management and Biosafety Control in Laboratory Animal Facilities [J]. Laboratory Animal and Comparative Medicine, 2021, 41(5): 443-449.
[15]	JIN You, WANG Chenchen, YU Shangbin, LUO Junyu, ZHOU Shunchang. Design of Two-dimensional Code Information Management System for Animal Corpses in Medical Experimental Teaching [J]. Laboratory Animal and Comparative Medicine, 2021, 41(5): 455-458.