Abstract: Objective To investigate the function of Compound Momordica Charantia L. capsule for reducing blood glucose. Methods Mice were injected with alloxan to build hyperglycemia animal model and then randomly divided into three test groups (225, 450, 900mg/kg) and model control group. The mice were administered with the compound for 30 days, then the fasting blood-glucose and sugar tolerance between test groups and control group were compared. Normal mice were chosen to carry out the test of reducing fasting blood - glucose at the same time. Results The fasting blood - glucose was obvious lower than that of model control group (P<0.01), and the blood-glucose decline rate was greater than that of control group (P<0.01) in the hyperglycemia model mice of 900 and 450 mg/kg group. There were not significant difference between the sugar tolerance of test groups and model control group in hyperglycemia model mice and between the fasting blood - glucose of test group and model control group in normal mice. Conclusion Compound momordica charantia L. capsule had the function for reducing blood-glucose.

Key words: Momordica charantia L., Mice, Blood-glucose reduction