Laboratory Animal and Comparative Medicine ›› 2012, Vol. 32 ›› Issue (1): 20-22.DOI: 10.3969/j.issn.1674-5817.2012.01.005

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Effect of HP-β-CD on Haematology and Serum Biochemical Parameters in SD Rats

ZHU Kui-cheng1,2, XUE Jing-li1, WANG Chun-yao1   

  1. 1. Laboratory Animal Center of Zhengzhou University, Zhengzhou 450052, China;
    2. Drug Safety Evaluation and Research Center of Zhengzhou University, Zhengzhou 450052, China
  • Received:2011-10-20 Online:2012-02-25 Published:2012-02-25

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Abstract: Objective To investigate the effects of HP-β-CD on clinical symptom, hematological parameters and blood biochemical parameters in rats. Methods Fourty SD rats were randomly divided into 4 groups. 6-week rats (SD) were administrated with HP-β-CD at doses of 500, 1000 and 2000 mg/kg/day by continuous intravenous infusion. Results There was no effect on survival and outer appearance and behavior comparing with control group. At both 1 000 and 2 000 mg/kg/day groups, there was a decrease in the number of RBC, content of Hb and HCT, while plasma BUN level increased (P<0.05 or P<0.01).It showed increasing in plasma CRE level at 2 000 mg/kg/day. Conclusion HP-β-CD could induce hemolysis and renal function damaged in rats at both 1 000 and 2 000 mg/kg/day dose.

Key words: HP-β-CD, Rat, Hematological parameter, Blood biochemical parameters

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