Effects of Aqueous Extract from Selaginella uncinata on Asthmatic Rats

doi:10.3969/j.issn.1674-5817.2011.04.012

Abstract

Abstract: Objective To investigate effects of aqueous extract from Selaginella uncinata on the level of IgE in serum and IL-5 in lung of the asthmatic rats. Method Sixty male SD rats were randomly divided into six groups. Then the asthma rats model were made by ovalbumin (OVA)-sensitized and stimulated method. The level of IgE and IL-5 were detected by enzyme-linked immunosorbent assay (ELISA). Result Compared with the normal control group, the levels of IgE and IL-5 in the asthmatic group were higher (P<0.01). The aqueous extract of Selaginella uncinata could decrease levels of IgE and IL-5. Conclusion The extract of Selaginella uncinata could effectively decrease IgE and IL-5 levels on asthma rats and improve the asthmatic symptoms.

Key words: Asthma, Rat, Selaginella uncinata, Aqueous extract, IgE, IL-5

CLC Number:

Q95-33

YU Bing. Effects of Aqueous Extract from Selaginella uncinata on Asthmatic Rats[J]. Laboratory Animal and Comparative Medicine, 2011, 31(4): 280-282.

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