Effects of Azone on Osmotic Absorption of Resveratrol in Zebrafish

doi:10.3969/j.issn.1674-5817.2011.02.008

Abstract

Abstract: Objective To study the effects of water-solubility azone on the transdermal absorption of resveratrol and teratogenicity. Methods The formation of neovascularization was inhibited by using resveratrol, the number of zebrafish dorsal aorta intersegmental blood flow were calculated added with water- solubility azone under fluorescent microscope, and teratogenic-action effects were recorded by water-solubility azone added for 24 h. Results The water -solubility azone at the coneentration of 0.01~0.5 µg/ml were safe to zebrafish embry, and the 0.5 µg/ml water-solubility azone showed significant transdermal absorption of resveratrol in zebrafish, intersegmental vessel number of dorsal aorta inhibition ratio could be 22.9%, the incidence of deformity can be occured. Conclusions The water-soluble azone with the Concentrations over 0.5 µg/ml have significant teratogenic effects on zebrafish embryos; and the 0.5 µg/ml water-solubility azone shows the optimal transdermal absorption of the resveratrol.

Key words: Azone, Resveratrol, Percutaneous absorption, Zebrafish

CLC Number:

Q95-33

CHEN Xi-qiang, HAN Li-wen, LIU Ke-chun, HOU Hai-rong, WANG Xi-min, HE Qiu-xia. Effects of Azone on Osmotic Absorption of Resveratrol in Zebrafish[J]. Laboratory Animal and Comparative Medicine, 2011, 31(2): 108-110.

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