Research Progress on Zebrafish Model of Retinoblastoma and rb1 Gene

doi:10.3969/j.issn.1674-5817.2019.03.013

Abstract

Abstract: Retinoblastoma (RB) is a common primary malignant tumor that occurs in the eyes of infants and young children. A large number of studies have shown that the change of rb1 gene is the main cause of RB occurrence. The zebrafish RB model is a novel animal model for studying RB. In this paper, the latest research results of rb1 gene, as well as the zebrafish RB model produced by xenograft method, gene mutation method, and TALEN gene editing method are reviewed. Furthermore, the RB zebrafish model was compared with the four kinds of reported RB animal models that were raised on mice, rat, rabbit or xenopus.

Key words: Retinoblastoma (RB), Zebrafish, rb1 gene

CLC Number:

Q95-33

WANG Li-mei, ZHANG Jian, LIU Zhong-hua, YANG Wei. Research Progress on Zebrafish Model of Retinoblastoma and rb1 Gene[J]. Laboratory Animal and Comparative Medicine, 2019, 39(3): 244-248.

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