Laboratory Animal and Comparative Medicine ›› 2011, Vol. 31 ›› Issue (2): 102-104.DOI: 10.3969/j.issn.1674-5817.2011.02.006

Previous Articles     Next Articles

Pathobiological Observation on Effect of Melamine on Renal Development in Neonatal Rat

SU Ping1, FENG Yang1, WU Yu1, LIU Zhi-tao1, CAI Shi-bin1, WANG Ji-hong2, DU Yong-hong3   

  1. 1. Chongqing Medical University Seven-year-program Student;
    2. Biochemistry and Molecular Biology Laboratory of Laboratorial Education Administration Center;
    3. Biomedical Engineering Department; Chongqing 400016,China
  • Received:2010-06-23 Online:2011-04-25 Published:2011-04-25

PDF (PC)

213

Abstract: Objective To observe the effect of melamine with different dosages on renal development in neonatal rats. Methods Fifty-six SD rats were randomly divided into 7 groups. groupM1-groupM6, fed with different dosages of melamine from the start of pregnancy, group M0 fed with distilled water at the same time. All neonatal rats on group M0 to M6 were sacrificed at the time of 12 h after deliver for conducting pathological examination on the kidneys. Results Compare to the control group (M0), the experimental groups showed different pathological changes with the different dosage of melamine. Conclusion By going through the placental barrier melamine could have a pathological effect on fetus kidney during pregnancy, and the degree of the effects relies on the dosage level of melamine.

Key words: Melamine, Neonatal, Kidney, Pathology

CLC Number: