Design of a Capture Stress-Free Marmoset Monkey Chair Device for Experiments and Its Preliminary Application

doi:10.12300/j.issn.1674-5817.2024.097

Abstract

Abstract:

Objective To avoid stress responses in experimental monkeys caused by direct capture, and to improve the adaptability and experimental efficiency of marmosets in behavioral, two-photon imaging, and electrophysiological experiments, a device for immobilizing marmosets without the need for capture is developed. Methods A set of compatible transport cage and monkey chair was produced through 3D graphic design and printing. First, the transport cage was aligned with the feeding outlet of the experimental housing cage, and the marmoset was gently guided into the transport cage. Then, the transport cage was connected to the monkey chair, and the marmoset was gently guided into the chair for immobilization. Subsequent experiments were carried out afterward. The effectiveness was evaluated by observing the efficiency of transport and immobilization, the marmoset cooperation level, and stress responses. Results After testing and improvements, the device successfully completed immobilization of marmosets without the need for capture, significantly improving the fluency and efficiency of the experiment. As the number of operations increased, the marmosets became more cooperative, and the operation speed was significantly enhanced. After using the device, the stress responses were noticeably reduced, with marmosets showing lower stress levels. In particular, compared to traditional capture methods, the use of this device significantly reduced marmoset anxiety and discomfort, increasing their cooperation levels during the experiment. Conclusion The monkey chair device designed allows for restraint of marmosets without the need for capture, ensuring smooth progress of subsequent experiments while also safeguarding animal welfare. This device is easy to operate, highly practical, cost-effective, and has great potential for widespread application.

Key words: Common marmoset, Monkey chair, Restraint device, Stress

CLC Number:

Q95-33

XU Shengye,HUANG Junfeng,CHEN Yihang,et al. Design of a Capture Stress-Free Marmoset Monkey Chair Device for Experiments and Its Preliminary Application[J]. Laboratory Animal and Comparative Medicine, 2025, 45(1): 67-72. DOI: 10.12300/j.issn.1674-5817.2024.097.

Figures/Tables 2

Figure 1 Schematic diagram of the transport cage and monkey chairNote： A， Front view of the transport cage； B， Left view of the transport cage； C， Top view of the transport cage； D， Side view of the transport cage； E， Push plate； F， Front view of the monkey chair； G， Left view of the monkey chair； H， Top view of the monkey chair； I， Side view of the monkey chair； J， Anti-collision cover. 1， Hook； 2， Rear panel of the transport cage； 3， Movable hook nut fixture block； 4， Locking nut hole for the panel； 5， Handle； 6， Main body of the transport cage； 7， Circular observation hole； 8， Front panel of the transport cage； 9， Front panel of the monkey chair； 10， Rear panel of the monkey chair； 11， Main body of the monkey chair； 12， Monkey chair clamping plate； 13， Adjustable base； 14， Fixed legs of the monkey chair.

Figure 2 Photos of the transport cage and monkey chairNote： A， Transport cage； B， Push plate； C， Monkey chair； D， Anti-collision cover.

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