关键词: 中药注射剂, 免疫毒性, 被动过敏试验, 主动过敏试验

Abstract: Objective To study the immunotoxicity difference of Breviscapine Injection between rat and guinea pig. Methods According to the Chinese traditional medicine, natural medicine immunity toxicity study technical directed principle, the PCA and ASA tests were carried out in order to compare the immunotoxicity difference between the two animals. Results The results of the allergy testing showed that no positive symptom in SD rat occurred at all the doses of 5 mg/kg、50 mg/kg and 500 mg/kg of Breviscapine injection group in PCA toxicity study. While in ASA toxicity study, 50 percent animals appeared weak positive and 50 percent animals appeared positive at the dose of 5 mg/kg of Breviscapine injection group; and all appeared the positive symptoms at the high dose of 50 mg/kg group. Conclusions Compared with the allergic response in animal study, there are significant difference between the PCA and the ASA toxicity study and the ASA is more sensitive and more conformity to the application in clinical.

Key words: Chinese traditional medicine injectas, Immunotoxicity, Passive cutaneous anaphylaxis test (PCA), Active systemic anaphylaxis(ASA)