[1] Decramer M,Janssens W,Miravitlles M.Chronic obstructive pulmonary disease[J].Lancet,2012,379(27):1341-1351. [2] Heijink IH,Brandenburg SM,Postma DS,et al.Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery[J].Eur Respir J,2012,39(2):419-428. [3] Proud D,Hudy MH,Wiehler S,et al.Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes[J].PLoS One,2012,7(7):e40762. [4] Xie XS,Yang M,Liu HC,et al.Ginsenoside Rg1,a major active component isolated from Panax notoginseng,restrains tubular epithelial to myofibroblast transition in vitro[J].J Ethnopharmacol,2009,122(1):35-41. [5] Yu M,Yu X,Guo D,et al.Ginsenoside Rg1 attenuates invasion and migration by inhibiting transforming growth factor-beta1-induced epithelial to mesenchymal transition in HepG2 cells[J].Mol Med Rep,2015,11(4):3167-3173. [6] Xie CL,Wang WW,Xue XD,et al.A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke[J].Sci Rep-Uk,2015,5:7790. [7] Yu HT,Zhen J,Pang B,et al.Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats[J].J Zhejiang Uuiv Sci B,2015,16(5):344-354. [8] Li SS,Ye JM,Deng ZY,et al.Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats[J].Ren Fail,2015(5),37:890-895. [9] Wang Y,Liu Y,Zhang XY,et al.Ginsenoside Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-kappaB and PI3K/Akt/mTOR pathways[J].Int Immunopharmacol,2014,23(1):77-84. [10] Xue CC,Shergis JL,Zhang AL,et al.Panax ginseng C.A Meyer root extract for moderate chronic obstructive pulmonary disease (COPD):study protocol for a randomised controlled trial[J].Trials,2011,12(1):164. [11] An X,Zhang AL,Yang AW,et al.Oral ginseng formulae for stable chronic obstructive pulmonary disease:a systematic review[J].Resp Med,2011,105(2):165-176. [12] 刘乾,刘松,徐卫国,等.泛素特异性蛋白酶19对烟熏诱导慢性阻塞性肺疾病大鼠模型骨骼肌萎缩的作用和机制[J].实验动物与比较医学,2017,37(3):185-190. [13] Zhao YL,Zhu RT,Sun YL.Epithelial-mesenchymal transition in liver fibrosis[J].Biomed Rep,2016,4(5):269-274. [14] Bennett J,Cassidy H,Slattery C,et al.Tacrolimus modulates TGF-beta signaling to induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells[J].J Clin Med,2016,5(5):50. [15] Zidar N,Bostjancic E,Jerala M,et al.Down-regulation of microRNAs of the miR-200 family and up-regulation of Snail and Slug in inflammatory bowel diseases - hallmark of epithelial-mesenchymal transition[J].J Cell Mol Med,2016,20(10):1813-1820. [16] Ijaz T,Pazdrak K,Kalita M,et al.Systems biology approaches to understanding epithelial mesenchymal transition (EMT) in mucosal remodeling and signaling in asthma[J].World Allergy Organ J,2014,7(1):1-14. [17] Sun H,Chen J,Qian W,et al.Integrated long non-coding RNA analyses identify novel regulators of epithelial-mesenchymal transition in the mouse model of pulmonary fibrosis[J].J Cell Mol Med,2016,20(7):1234-1246. [18] Mahmood MQ,Sohal SS,Shukla SD,et al.Epithelial mesenchymal transition in smokers:large versus small airways and relation to airflow obstruction[J].Int J Clin Exp Med,2015,10(1):1515-1524. |