新型吡啶类鬼臼毒素衍生物对淡色库蚊的生物活性研究

›› 2006, Vol. 26 ›› Issue (3): 144-147.

新型吡啶类鬼臼毒素衍生物对淡色库蚊的生物活性研究

南京医科大学应用毒理研究所神经毒理室,南京 210029

收稿日期:2006-05-31 出版日期:2006-09-25 发布日期:2006-09-25
基金资助:
国家自然科学基金资助项目(批准号:30371169)

Insecticidal Activity of Twelve Novel Pyridine Ring Derivatives of Podophyllotoxin

Institute of Applied Toxicology of Nanjing Medical University, Nanjing 210029, China

Received:2006-05-31 Online:2006-09-25 Published:2006-09-25

摘要/Abstract

摘要： 目的研究新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的的毒杀活性。方法采用WHO生物测试法测定吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的毒杀活性。结果 12种新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的毒杀作用有明显的差异，化合物4.4、4.5和4.6的毒杀作用明显高于其它化合物。结论 12种新型吡啶类鬼臼毒素衍生物对3龄初淡色库蚊幼虫毒杀作用的差异可能与结构上的差异有关。

关键词: 吡啶类鬼臼毒素, 淡色库蚊, 植物源杀虫剂

Abstract: Objective The bioactivity of twelve novel pyridine ring derivatives of podophyllotoxin were tested against 3rd instar larvae of Culex pipiens pallens. Methods Using WHO bioassay method. Results From twelve novel pyridine ring derivatives of podophyllotoxin, three compounds 4.4、4.5 and 4.6 have more higher toxicities than others, and the LC₅₀ were 1.66, 3.96 and 1.54 mg/L respectively. Conclusion Based on the data obtained in this investigation, it is possible that the dissimilarity in the structure of the analogues leads to their different bioactivity.

Key words: Pyridine ring derivatives of podophyllotoxin, Culex pipiens pallensl, Botanical insecticide

刘艳青, 张守刚, 程洁, 肖杭, 高蓉. 新型吡啶类鬼臼毒素衍生物对淡色库蚊的生物活性研究[J]. , 2006, 26(3): 144-147.

LIU Yan-Qing, ZHANG Shou-Gang, CHENG Jie, XIAO Hang, GAO Rong. Insecticidal Activity of Twelve Novel Pyridine Ring Derivatives of Podophyllotoxin[J]. , 2006, 26(3): 144-147.