实验动物与比较医学 ›› 2006, Vol. 26 ›› Issue (3): 144-147.
• 论文 •
基金资助:
国家自然科学基金资助项目(批准号:30371169)
摘要： 目的 研究新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的的毒杀活性。方法 采用WHO生物测试法测定吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的毒杀活性。结果 12种新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的毒杀作用有明显的差异，化合物4.4、4.5和4.6的毒杀作用明显高于其它化合物。结论 12种新型吡啶类鬼臼毒素衍生物对3龄初淡色库蚊幼虫毒杀作用的差异可能与结构上的差异有关。
Abstract: Objective The bioactivity of twelve novel pyridine ring derivatives of podophyllotoxin were tested against 3rd instar larvae of Culex pipiens pallens. Methods Using WHO bioassay method. Results From twelve novel pyridine ring derivatives of podophyllotoxin, three compounds 4.4、4.5 and 4.6 have more higher toxicities than others, and the LC50 were 1.66, 3.96 and 1.54 mg/L respectively. Conclusion Based on the data obtained in this investigation, it is possible that the dissimilarity in the structure of the analogues leads to their different bioactivity.
. Insecticidal Activity of Twelve Novel Pyridine Ring Derivatives of Podophyllotoxin[J]. Laboratory Animal and Comparative Medicine, 2006, 26(3): 144-147.
/ / 推荐
导出引用管理器 EndNote|Ris|BibTeX
链接本文: https://www.slarc.org.cn/dwyx/CN/
https://www.slarc.org.cn/dwyx/CN/Y2006/V26/I3/144
