关键词: 冠状动脉, 支架植入术, 凝血, 血小板

Abstract: To study the effect of coronary stent implantation on the coagulation and platelet function of rabbits, eighteen New Zealand white male rabbits were underwent precutaneous transluminal coronary stenting. Their blood samples were collected before and at 1，2，4，24 hour after the stent implantation, respectively. The coagulant parameters of thrombin time （TT）, prothrombin time （PT）, activated partial thromboplastin time （APTT） and the fibrinogen, P-Selectin and thromboxane B₂ （TxB₂） level in plasma, platelet number, and tested platelet aggregation function were detected. The coagulation parameters of TT, PT, APTT had no significant change after the stent implantation, but the platelet number and the fibrinogen level in plasma was decrease after stent implantation and came back to the normal level in the 24 hour after the surgery. The level of platelet aggregation rate and P-Selectin and TxB₂ in plasma was higher after the stent implantation. Therefore, the coronary stent implantation had significant effect on the platelet activation，thrombosis and the activation of congulant system, It was approved that it is necessary to inspect the platelet activation and therapy with antithrombotic medicine after the stent implantation simultaneously.

Key words: Coronary artery, Stent implantation, Coagulation, Platelet