实验动物与比较医学 ›› 2026, Vol. 46 ›› Issue (1): 107-118.DOI: 10.12300/j.issn.1674-5817.2025.049

• 实验动物质量控制 • 上一篇    下一篇

普通狨猴饲养繁育与遗传管理经验探讨

李莉, 李学波, 樊永恒, 贺东华, 李剑洪, 常亮堂()()   

  1. 中国科学院脑科学与智能技术卓越创新中心实验动物中心, 上海 200031
  • 收稿日期:2025-03-25 修回日期:2025-07-14 出版日期:2026-02-25 发布日期:2026-02-14
  • 通讯作者: 常亮堂(1982—),男,硕士,高级实验师,研究方向:灵长类行为实验研究。E-mail: changliangtang@ion.ac.cn。ORCID: 0009-0000-5308-3792
  • 作者简介:李莉(1996—),女,硕士,实验师,研究方向:实验动物医学。E-mail: lil@ion.ac.cn

Experience Discussion on Feeding, Breeding and Genetic Management of Common Marmosets (Callithrix jacchus)

LI Li, LI Xuebo, FAN Yongheng, HE Donghua, LI Jianhong, CHANG Liangtang()()   

  1. Laboratory Animal Center, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
  • Received:2025-03-25 Revised:2025-07-14 Published:2026-02-25 Online:2026-02-14
  • Contact: CHANG Liangtang (ORCID: 0009-0000-5308-3792), E-mail: changliangtang@ion.ac.cn

摘要:

普通狨猴(common marmoset,Callithrix jacchus)是灵长目狨科狨属动物。普通狨猴是研究神经科学、医学、药学的重要科研资源,普通狨猴动物资源的饲养繁育是重要的科研支撑。目前,中国普通狨猴资源正处于发展的重要阶段。本文以中国科学院脑科学与智能技术卓越创新中心(以下简称本中心)为例,深入探讨普通狨猴饲养繁育与遗传管理经验。在饲养环境及设施方面,在国家标准基础上对环境温度、相对湿度、换气次数、沉降菌平均浓度执行更为严格的环境参数标准,设计了普通狨猴繁殖和实验的2种饲养笼具;依据设施和人力条件的不同,介绍了“干养”和“湿养”结合的清洁维护模式。在饲喂管理方面,为满足普通狨猴高营养需求自制特殊日粮,介绍了普通狨猴由自制日粮和颗粒料混合食物向纯商品粮饲喂的过渡方法,严格把控自制普通狨猴日粮的操作环节并积累一系列预防普通狨猴营养代谢病的方法。在动物健康管理方面,通过定期检疫、隔离治疗和流行病预防等措施保障普通狨猴健康,详细说明了普通狨猴健康检查流程,随后依据普通狨猴体况进行分级分类管理,并简要介绍了普通狨猴常见的腹泻和肺炎的治疗方法。在繁育管理方面,涵盖种猴挑选、配种合笼、分笼管理及仔猴人工饲养,并从动物福利角度介绍了人工饲养仔猴回归亲代的饲养方法。在遗传管理方面,本中心普通狨猴为封闭群,采用的是非近亲繁殖法,开发了近亲筛查系统,在动物配对前查询近亲信息以避免近亲繁殖;本中心在不从外部引入新个体的条件下,已连续繁殖5代,遗传组成具有杂合性。本文仅探讨普通狨猴的饲养繁育及遗传管理,以期为其他饲养普通狨猴的机构提供有益借鉴。

关键词: 普通狨猴, 狨猴繁育, 饲养管理, 健康管理, 遗传管理

Abstract:

The common marmoset (Callithrix jacchus) is a species of the genus Callithrix in the primate family Callitrichidae. Common marmosets are an important scientific research resource for the study of neuroscience, medicine, and pharmacy. The feeding and breeding of common marmosets provide important support for scientific research. At present, common marmoset resources in China are at a critical stage of development. This paper takes the Center for Excellence in Brain Science and Intelligence Technology of the Chinese Academy of Sciences (hereafter referred to as CEBSIT) as an example to discuss the experience of common marmoset feeding, breeding and genetic management. In terms of breeding environment and facilities, on the basis of the national standard, more stringent environmental parameter standards are implemented for environmental temperature, relative humidity, the number of air exchanges, and the average concentration of sedimentation bacteria. Two kinds of cages for common marmoset breeding and experimentation are designed. According to the differences in facility conditions and staffing, a cleaning and maintenance method combining "dry rearing" and "wet rearing" is introduced. In terms of feeding management, in order to meet the high nutritional needs of common marmosets, CEBSIT prepares special formulated diets, and introduces the transition method of common marmosets from diets mixed with formulated rations and pellets to exclusive commercial diets, and strictly regulates the operation procedures of formulated diets for common marmosets, and has accumulated a series of methods for preventing nutritional and metabolic diseases in common marmosets. In terms of animal health management, the health of common marmosets is ensured through measures such as regular quarantine, isolation and treatment, and epidemic prevention, and the health inspection process of common marmosets is described in detail, and hierarchical and classified management is carried out according to the physical condition of common marmosets. This paper also briefly describes the treatment of diarrhea and pneumonia that are common in common marmosets. In terms of breeding management, it covers the selection of breeding common marmosets, combining pairs of common marmosets into the same cage for breeding, group splitting and hand-rearing of infant common marmosets, and introduces the method of reintroducing hand-reared infant common marmosets to parental care from the perspective of animal welfare. In terms of genetic management, the common marmoset population in CEBSIT is maintained as a closed colony and follows a non-inbreeding method. CEBSIT has developed an inbreeding screening system to check pedigree information before pairing to avoid inbreeding. Under conditions without introducing new individuals from outside, CEBSIT has continuously bred the colony for 5 generations while maintaining genetic heterozygosity. This paper only discusses the feeding, breeding and genetic management of the common marmoset and aims to provide a useful reference for other institutions engaged in common marmoset breeding.

Key words: Common marmoset, Breeding of common marmoset, Feeding management, Health management, Genetic management

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