关键词: SCID小鼠, 脏器质量, 血液生理生化, 免疫球蛋白, 补体, 免疫细胞

Abstract: Objective To determinate the main organ weights,blood physiological and biochemical indexes,immunoglobulins,complements and immune cells data of SCID mice.Methods Twenty SCID mice at the age of 4,8 and 16 weeks old respectively,with half male and female,were selected for detecting the main organ weight,blood physiology and biochemistry indexes,immunoglobulins and complements data.Twenty SCID mice at the age of 8 weeks old,with half male and female,were selected for detecting T cells and subgroups,B cells,and NK cells.Results The thymus weight of SCID mice was independent of gender and age,and there was no significant difference.The levels of red blood cell,lymphocyte,IgG,IgA and IgM in the 4-week-old SCID mice were significantly greater than those in 8 weeks and 16 weeks.T cells,B cells,and NK cells,separated and sampled from spleen,are no significant difference in gender.CD3+ was the smallest proportion in total immune cells,and B220+ accounted for the largest proportion.Conclusions SCID mice are immunodeficiency animals of T and B cells comprised.The blood physiological and biochemical data of this experiment were basically consistent with the data of SCID mice abroad.It shows that the biological characteristics,such as heredity character,physiology biochemistry of this strain have not changed since the introduction.

Key words: SCID mice, Organ weights, Blood physiology and biochemistry indexes, Immunoglobulins, Complements, Immune cells