[1] Yu WM, Daino H, Chen J, et al.Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling[J]. J Biol Chem, 2006, 281(9):5426-5434. [2] Qu CK, Nguyen S, Chen J, et al.Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development[J]. Blood, 2001, 97(4):911-914. [3] Wang S, Yu WM, Zhang W, et al.Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase(PTPN11) enhance cell migration and angiogenesis[J]. J Biol Chem, 2009, 284(2):913-920. [4] Xu D, Wang S, Yu WM, et al.A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells[J]. Blood, 2010, 116(18):3611-3621. [5] Martinelli S, Nardozza AP, Delle Vigne S, et al.Counteracting effects operating on Src-homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome[J]. J Biol Chem, 2012, 287(32):27066-27077. [6] Araki T, Mohi MG, Ismat FA, et al.Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation[J]. Nat Med, 2004, 10(8):849-857. [7] 胡中倩, 汪心怡, 储著朗, 等. SHP-2酪氨酸磷酸酶激活突变促进组织白细胞浸润和器官损伤[J]. 中国比较医学杂志, 2011, 21(12):10-14. [8] 霍寅萍, 储著朗, 余科科, 等. SHP-2酪氨酸磷酸酶激活突变的肥大细胞对IL3呈高增殖敏感性[J]. 安徽医科大学学报, 2010, (05):593-596. [9] Nishida K, Yamasaki S, Hasegawa A, et al.Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation[J]. J Immunol, 2011, 187(2):932-941. [10] Maus M, Medgyesi D, Kovesdi D, et al.Grb2 associated binder 2 couples B-cell receptor to cell survival[J]. Cell Signal, 2009, 21(2):220-227. [11] Vaughan TY, Verma S, Bunting KD.Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology[J]. Am J Blood Res, 2011, 1(2):130-134. [12] Cha Y,Park KS.SHP-2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells[J]. FEBS Lett, 2010, 584(19):4241-4246. [13] Grossmann KS.The tyrosine phosphatase Shp2 in development and cancer[J]. Adv Cancer Res, 2010, 106:53-89. [14] Xu D, Liu X, Yu WM, et al.Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells[J]. J Exp Med,2011, 208(10):1977-1988. [15] 杨金莲, 卢艳敏, 杨帆, 等. 白血病相关的激活突变SHP-2对小鼠体内血管新生能力的影响[J]. 实验动物与比较医学, 2012, 32(4):259-264. [16] 张凤英, 余科科, 李菲菲, 等. SHP-2酪氨酸磷酸酶激活突变促进白细胞黏附和迁移的观察[J]. 安徽医科大学学报,2010, 45(4):487-490. |