非人灵长类实验动物用于人类卵巢衰老研究进展

doi:10.12300/j.issn.1674-5817.2024.114

实验动物与比较医学 ›› 2025, Vol. 45 ›› Issue (1): 47-54.DOI: 10.12300/j.issn.1674-5817.2024.114

非人灵长类实验动物用于人类卵巢衰老研究进展

肖文娴¹^,²()(), 吕龙宝¹^,²^,³()()

^1.中国科学院昆明动物研究所, 昆明 650223
^2.国家非人灵长类实验动物资源库, 昆明 650223
^3.中国科学院大学, 北京 100049

收稿日期:2024-08-02 修回日期:2024-12-04 出版日期:2025-03-12 发布日期:2025-02-25
通讯作者: 吕龙宝（1974—），男，硕士，正高级工程师，研究方向：实验动物学。E-mail： lvlongbao@mail.kiz.ac.cn。ORCID： 0000-0002-8437-6333
作者简介:肖文娴（1997—），女，硕士，工程师，研究方向：实验动物学。E-mail： xiaowenxian@mail.kiz.ac.cn。ORCID： 0009-0009-8336-5649
基金资助:
国家重点研发计划“灵长类实验动物育种、繁育、SPF猴培育及资源保护研究”(2022YFF0710900);云南（昆明）院士专家工作站计划“云南（昆明）贺争鸣实验动物专家工作站”(YSZJGZZ-2022063);云南省院士专家工作站“云南省贺争鸣专家工作站”(202305AF150160)

Research Progress on Human Ovarian Aging Using Non-Human Primates as Laboratory Animals

XIAO Wenxian¹^,²()(), LÜ Longbao¹^,²^,³()()

^1.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
^2.National Resource Center for Non-Human Primates, Kunming 650223, China
^3.University of Chinese Academy of Sciences, Beijing 100049, China

Received:2024-08-02 Revised:2024-12-04 Published:2025-02-25 Online:2025-03-12
Contact: LÜ Longbao (ORCID:0000-0002-8437-6333), E-mail: lvlongbao@mail.kiz.ac.cn

摘要/Abstract

摘要：

卵巢具有卵泡发生与激素分泌两大功能，与女性的生殖能力密切相关。卵巢衰老表现为卵巢形态改变、卵子数量减少和激素水平变化，不仅导致女性生育力下降，也被认为是多器官衰老的始动因素。此外，卵巢衰老伴随的性激素分泌紊乱还可能诱发心血管疾病、睡眠障碍、潮热等疾病和症状。由于社会压力与自身职业规划等因素的影响，现代女性的生育年龄普遍延迟，而卵巢功能的衰老进程却不会随年龄的增加而减缓。许多女性面临着想要生育时，却已错过最佳适育年龄，出现不孕不育等问题。这使人们日益关注延缓卵巢衰老的研究。非人灵长类实验动物在进化上与人类的亲缘关系最为接近，与人类基因组的序列同一性高达93%，因此在生理代谢、生殖内分泌、发育衰老等研究中具有其他模式动物无法比拟的优点，在非人灵长类实验动物上得到的研究结果转化应用到人类医学上也更为可靠。本文首先从卵巢衰老与治疗现状为切入点，概述非人灵长类实验动物作为卵巢衰老研究模式动物的优势，接着从生殖内分泌激素水平、卵巢的形态结构与功能、卵巢衰老的其他生理变化等方面。综述了非人灵长类实验动物应用于卵巢衰老研究的进展，并对存在的问题与展望进行总结，以期对读者有所帮助。

关键词: 非人灵长类实验动物, 卵巢衰老, 性激素, 卵泡

Abstract:

The ovary has two main functions: folliculogenesis and hormone secretion, both of which are closely related to female fertility. Ovarian aging is characterized by morphological changes, a reduction in follicle numbers, and fluctuations in hormone levels. It not only leads to a decline in female fertility, but is also considered to be a key driver of multi-organ aging. In addition, the disruption of sex hormone secretion associated with ovarian aging can lead to the occurrence of related diseases and symptoms, such as cardiovascular diseases, sleep disorders, and hot flashes. Due to the influence of social pressures and personal career planning, many modern women are increasingly postponing childbearing. However, ovarian aging does not slow down with advancing age. As a result, many women face issues such as infertility when they are ready to have children, having missed their optimal childbearing age. This leads to growing interest in research on delaying ovarian aging. Non-human primates share the closest evolutionary relationship with humans, with a genomic sequence identity of 93%, which grants them unparalleled advantages over other model animals in studies on physiological metabolism, reproductive endocrinology, and developmental aging. Findings obtained in non-human primates are also more reliably translatable to human medical research. This study begins by discussing the current state of ovarian aging research and treatment strategies, highlighting the advantages of non-human primates as laboratory animals for ovarian aging research. It then reviews research progress in areas such as reproductive endocrine hormone levels, ovarian morphology and function, and other physiological changes associated with ovarian aging. Furthermore, it summarizes existing challenges and future research directions, aiming to provide valuable insights for researchers.

Key words: Laboratory non-human primates, Ovarian aging, Sex hormones, Follicles

中图分类号:

R-332

肖文娴,吕龙宝. 非人灵长类实验动物用于人类卵巢衰老研究进展[J]. 实验动物与比较医学, 2025, 45(1): 47-54. DOI: 10.12300/j.issn.1674-5817.2024.114.

XIAO Wenxian,Lü Longbao. Research Progress on Human Ovarian Aging Using Non-Human Primates as Laboratory Animals[J]. Laboratory Animal and Comparative Medicine, 2025, 45(1): 47-54. DOI: 10.12300/j.issn.1674-5817.2024.114.

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非人灵长类实验动物用于人类卵巢衰老研究进展

Research Progress on Human Ovarian Aging Using Non-Human Primates as Laboratory Animals

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