Research Progress in Rat Models of Intrauterine Adhesion

doi:10.12300/j.issn.1674-5817.2022.025

Abstract

Abstract:

Intact endometrium and proper endometrial thickness are the necessary conditions for normal uterine reproductive function. Intrauterine adhesion (IUA) can cause recurrent abortion and infertility, which seriously affects the normal reproductive function of patients. At present, the treatment methods for IUA include surgery elimination and use of estrogen, but there are problems such as poor effectiveness, high rate of recurrence, and still with low pregnancy rate. The specific pathogenesis and developmental mechanism of IUA and the repair mechanism of damaged endometrium are still unclear. Establishing an appropriate animal model is conducive to the research of human IUA in all aspects. Here, we introduced the common rat models of IUA in recent years, including physical and mechanical damage method, chemical damage method, biological damage method and combined damage method, and described its application from the aspects of modeling rate, stability, and pathogenesis of IUA, and discussed the observation indexes to evaluate the success of modeling, in order to provide useful reference for selecting appropriate modeling methods. Generally, the combined model of repeated endometrial damage and infection of pregnant rats may be more suitable for the clinical IUA caused by multiple abortions and infections after curettage.

Key words: Intrauterine adhesion, Animal model, Rat

CLC Number:

Q95-33

Shaofeng HUANG, Zhong LIN, Xuehong ZHU, Shuchen LIU, Li BIN. Research Progress in Rat Models of Intrauterine Adhesion[J]. Laboratory Animal and Comparative Medicine, 2022, 42(6): 560-565.

Figures/Tables 2

References 31

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动物种类 Animal species	繁殖能力 Fertility	生殖周期 Reproductive cycle	价格 Price	遗传背景 Genetic background	操作难度 Operation difficulty	试验周期 Test cycle
小鼠 Mouse	生育力强，多产	妊娠期及经期短	低廉	来源明确，基因型稳定	易操作	短
大鼠 Rat	生育力强，多产	妊娠期及经期短	低廉	来源明确，基因型稳定	易操作	短
新西兰白兔 New Zealand white rabbit	生育力强，多产	妊娠期长短不定（32～36 d)	一般	来源明确，基因型稳定	易操作	短
比格犬 Beagle	季节性繁殖，每窝产仔数相对较少	妊娠期约55～65 d，经期约7～14 d	较高	有近亲繁殖因素存在，组织学背景资料不足	难操作	中等
非人灵长类 Non-human primate	每胎产仔数相对很少	妊娠期及经期与人类相近	昂贵	组织学背景资料不足	难操作	长

动物种类 Animal species	繁殖能力 Fertility	生殖周期 Reproductive cycle	价格 Price	遗传背景 Genetic background	操作难度 Operation difficulty	试验周期 Test cycle
小鼠 Mouse	生育力强，多产	妊娠期及经期短	低廉	来源明确，基因型稳定	易操作	短
大鼠 Rat	生育力强，多产	妊娠期及经期短	低廉	来源明确，基因型稳定	易操作	短
新西兰白兔 New Zealand white rabbit	生育力强，多产	妊娠期长短不定（32～36 d)	一般	来源明确，基因型稳定	易操作	短
比格犬 Beagle	季节性繁殖，每窝产仔数相对较少	妊娠期约55～65 d，经期约7～14 d	较高	有近亲繁殖因素存在，组织学背景资料不足	难操作	中等
非人灵长类 Non-human primate	每胎产仔数相对很少	妊娠期及经期与人类相近	昂贵	组织学背景资料不足	难操作	长

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