Abstract: Objective To investigate a dynamic curve of blood biochemical and physiological characteristics in the process of inbreeding ischemia-prone gerbil,and to provide basic data for inbred animal breeding.Methods The 17 blood biochemical and 22 physiological indices of blood samples from inbred 11th to 20th generation (F11 to F20) were detectioned by Beckman automatic biochemical analyzer (CX5) and Japanese photoelectric automatic blood cell analyzer (MEK-7222K).Results The results showed that the uricacidcrystal (URIC),lactate dehydrogenase (LD),creatine kinase (CK),alanine aminotransferase (ALT),high density lipoproteins (HDLD),magnesium (MG),red blood cell (RBC),leukocyte (WBC),eosinophil (EOS),neutrophil count (NEUT),monocytes (MON),basophilic granulocyte(BAS),blood platelet (PLT),thrombocytocrit (PCT),platelet distribution width (PDW),hemoglobin(HGB),mean corpuscular hemoglobin (MCH),and red blood cell distribution width (RDW) of F11-20 gerbil were increasing.The lymphocyte (LYM),creatinine (CRE),blood urea nitrogen (BUN),alkaline phosphatase (ALP),glucose (GLU) showed a decreasing trend.The hematocrit (HCT),mean corpuscular volume (MCV),mean corpuscular hemoglobin concentration (MCHC),average platelet volume (MPV) value was stable.The majority of indicators tend to be stable after F17.Conclusion The gerbil inbred strain has a certain influence on the most of the blood physiological and biochemical indices.

Key words: Gerbil, Inbred, Ischemia model, Biochemical characteristics, Physiological index