Observation on Micro- and Ultra-structures of the Lung in Naked Mole Rar (Heterocephalus glaber)

doi:10.3969/j.issn.1674-5817.2013.05.012

Abstract

Abstract: Objective To observe and analyze the the morphological structure and composition of lung in the naked mole rat (Heterocephalus glaber). Method The lungs were isolated from anaesthetic animals and then made to paraffin sections, which were stained by hematoxylin-eosin (HE) dye. The microstructure of lung was observed under optical microscope. Meanwhile, the fresh lungs were processed to ultrathin sections and stained. At last, the ultramicroscopic structure of lungs was observed by transmission electron microscope. Result The lungs of NMR looks like bronchiectasis and pulmonary atelectasis observation through optical microscope. Besides, the distribution of vasculars and bronchial epithelial cells are quite different from mice. And, the surface of alveolar epithelial cells in NMR are rich in microvilli. Moreover, the blood-gas barrier of NMR is thiker then mice’s. Conclusion The lungs of NMR show infantile development. More importantly, NMR can open or close alveolar according to the body’s metabolic rate and oxygen demand.

Key words: Naked mole rat, Lung, Microstructure, Ultrastructure

CLC Number:

Q95-33

YUAN Zi-yan, ZHAO Yi-ning, ZHANG Lu, ZHAO Shan-min, LIN Li-fang, TANG Qiu, Sun Wei, YU Chen-ling, CAI Li-ping, XU Chen, CUI Shu-fang. Observation on Micro- and Ultra-structures of the Lung in Naked Mole Rar (Heterocephalus glaber)[J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 378-382.

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