Observation on Microstructure and Ultrastructure of Liver in Naked Mole Rat

doi:10.3969/j.issn.1674-5817.2013.05.011

Abstract

Abstract: Objective To observe and analyze the morphological structure and composition of the liver in naked mole rats. Method The liver of naked mole rat was isolated from anaesthetic naked mole rat and then made to paraffin section and hematoxylin-eosin(HE) staining, and the tissue structure was observed under common microscope.After freezing ultrathin sectioning and staining, the ultramicroscopic structure of the liver were observed by transmission electron microscope. Result The naked mole rats liver is rich in blood vessels,and the hepatic cell is larger than mice but glycogen is scarce under optical microscope. Transmission electron microscope show naked mole rat is rich in such organelles that involve in protein synthesis, such as mitochondria and rough endoplasmic reticulum. Besides,naked mole rat hepatic cells have signifficent number of smooth endoplasmic reticulum , lysosomal and autophagosome. Conclusion Naked mole rats liver has strong ability of metabolism, detoxification, and the ability to degrade damaged proteins and organelles.

Key words: Naked mole rat, Liver, Microstructure, Ultrastructure, Founction

CLC Number:

Q95-33

YUAN Zi-yan, ZHAO Yi-ning, ZHANG Lu, ZHAO Shan-min, LIN Li-fang, TANG Qiu, Sun Wei, YU Chen-ling, CAI Li-ping, XU Chen, CUI Shu-fang. Observation on Microstructure and Ultrastructure of Liver in Naked Mole Rat[J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 373-377.

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