Abstract: The activities of alkaline phosphatase （AKP） and acid phosphatase （ACP）in the hearts,livers and kidneys of KM mice at different stages of development were measured with enzyme histochemical method at 4,8,12,24 and 36 h after the mice being subjected to heat shock（44℃，30 min）. The results showed ：① The sensitivities of mice to heat shock at different stages of development were differed. The mice after birth were more sensitive than the fetuses.② Heat shock could induce the expression of AKP in the heart.③ Heat shock induced significant increase in the activities of AKP and ACP in the liver and kidney,and of ACP in the heart. The results suggested that AKP and ACP may play an important role in maintaining the normal physiological function of the cells in the heat shock responses.

Key words: Heat shock response, Mouse, Alkaline phosphatase, Acid phosphatase, Enzyme histochemistry