Abstract: "The establishment of NJS strain mouse as atherosclerosis model,including the origin,breeding objectives，breeding method, reproductive system，care and management were reported. The problem of decreasing in reproductive performence, the change of serum cholesterol level during the course of inbreeding and directive selection，and the feasibility of breeding method were discussed. "

Key words: "NJS strain, Inbreeding, Directive breeding, Mouse, Serum cholesterol level, Atherosclerosis model "