Comparison of the Anesthetic Effects of Different Doses of Ketamine Hydrochloride Combined Xylazine on Short-term Anesthesia in Bama Miniature Pigs

doi:10.12300/j.issn.1674-5817.2021.127

Abstract

Abstract:

Objectives To perform the combined anesthesia of ketamine hydrochloride and xylazine in miniature pigs, and to analyze the effect of drug dose on anesthesia.Methods Thirty-six Bama miniature pigs were randomly divided into three groups. Group A was administered with ketamine hydrochloride (10 mg/kg) + xylazine (2 mg/kg). Group B was administered with ketamine hydrochloride (10 mg/kg) + xylazine (1.5 mg/kg). Group C was administered with ketamine hydrochloride (5 mg/kg) + xylazine (2 mg/kg), and anesthesia monitoring indexes were recorded.Results There were no significant differences in anesthesia onset time and awake time between groups A and B (P > 0.05), and the awake time of anesthesia in groups A and B was significantly longer than that in group C (P < 0.05).Conclusion Ketamine hydrochloride (10 mg/kg) combined with xylazine (1.5?2 mg/kg) anesthesia has a rapid effect, stable anesthesia depth, no obvious movement, and satisfactory safety. It can be used in short procedures, diagnoses, and treatments.

Key words: Ketamine hydrochloride, Xylazine, Bama miniature pig, Combined anesthesia

CLC Number:

Q95-33

Chen SHEN, Baojie ZHANG, Xuemin WANG, jinyan ZHU, Min ZHANG, Bin LI. Comparison of the Anesthetic Effects of Different Doses of Ketamine Hydrochloride Combined Xylazine on Short-term Anesthesia in Bama Miniature Pigs[J]. Laboratory Animal and Comparative Medicine, 2022, 42(3): 262-265.

Figures/Tables 2

References 7

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项目 Items	A组 Group A	B组 Group B	C组 Group C	P值 P value
肌酐 Creatinine c/(μmol·L^-1)	66.25 ± 10.08	70.25 ± 13.10	70.58 ± 13.00	0.627
尿素氮 Urea nitrogen c/(mmol·L^-1)	2.73 ± 1.00	2.83 ± 1.01	2.16 ± 0.83	0.181
谷丙转氨酶 Alanine aminotransferase z/(U·L^-1)	71.17 ± 12.81	84.42 ± 15.10	85.08 ± 13.51	0.031
谷草转氨酶 Aspartate aminotransferase z/(U·L^-1)	48.83 ± 25.51	47.83 ± 15.07	52.33 ± 17.23	0.600
碱性磷酸酶 Alkaline phosphatase z/(U·L^-1)	114.50 ± 73.07	99.42 ± 48.44	103.67 ± 39.21	0.806
总胆红素 Total bilirubin c/(μmol·L^-1)	4.00± 0.95	3.83 ± 1.03	4.17 ± 1.99	0.934

项目 Items	A组 Group A	B组 Group B	C组 Group C	P值 P value
肌酐 Creatinine c/(μmol·L^-1)	66.25 ± 10.08	70.25 ± 13.10	70.58 ± 13.00	0.627
尿素氮 Urea nitrogen c/(mmol·L^-1)	2.73 ± 1.00	2.83 ± 1.01	2.16 ± 0.83	0.181
谷丙转氨酶 Alanine aminotransferase z/(U·L^-1)	71.17 ± 12.81	84.42 ± 15.10	85.08 ± 13.51	0.031
谷草转氨酶 Aspartate aminotransferase z/(U·L^-1)	48.83 ± 25.51	47.83 ± 15.07	52.33 ± 17.23	0.600
碱性磷酸酶 Alkaline phosphatase z/(U·L^-1)	114.50 ± 73.07	99.42 ± 48.44	103.67 ± 39.21	0.806
总胆红素 Total bilirubin c/(μmol·L^-1)	4.00± 0.95	3.83 ± 1.03	4.17 ± 1.99	0.934

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