Observation on Micro- and Ultra-structures of Heart in Naked Mole Rat (Heterocephalus glaber)

doi:10.3969/j.issn.1674-5817.2013.05.013

Abstract

Abstract: Objective To observe and analyze the the morphological structure and composition of heart in naked mole rat (Heterocephalus glaber). Method The hearts were isolated from anaesthetic naked mole rat and then made to paraffin sections, which were stained by hematoxylin-eosin(HE) dye. The microstructure of heart was observed under optical microscope. Meanwhile, the fresh hearts were processed to ultrathin sections and stained for ultra structure observation by transmission electron microscope. Result NMRs cardiac volume is bigger than that of mice, and heart wall is significantly thicker, and myocardial cell size is also larger too. There are more blood vessels in myocardium, and diameter of blood vessels is larger than mice. The number of mitochondria in NMR myocardial is larger, but the volume of mitochondrias is smaller. There are a few chemic injuries in sarcomere, but mitochondria structure is normal. Conclusion The heart of naked mole rat has generateed many adaptive changes for the chronically hypoxic lifestyle.

Key words: Naked mole rat, Heart, Microstructure, Ultrastructure

CLC Number:

Q95-33

YUAN Zi-yan, ZHAO Yi-ning, ZHANG Lu, ZHAO Shan-min, LIN Li-fang, TANG Qiu, Sun Wei, YU Chen-ling, CAI Li-ping, XU Chen, CUI Shu-fang. Observation on Micro- and Ultra-structures of Heart in Naked Mole Rat (Heterocephalus glaber)[J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 383-387.

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