The Antibody against Measles through Maternal-transferred and Immuno-response to First Measles Vaccine in Macaca fascicularis Infants

doi:10.3969/j.issn.1674-5817.2013.05.004

Abstract

Abstract: Objective To study the maternal-transferred measles antibody in order to know the optimal first measles vaccine-inoculated on Macaca fascicularis infants. Methods The 63 mother Macaca fascicularis ,with measles antibody negative,were selected after weaning, and 58 of them were vaccinated with measles and randomly averaged into two groups. Another five female didn’t vaccinate as the third group. The females of all the groups were mated with fertile male monkeys, the measles antibody were continuously tested in mothers and their infants. Results There was great correlation between maternal measles antibody level and newborn, and growth with age,maternal transferred measles antibody levels in newborns reduced gradually, up to 5 month, antibody titer less than 7%. After 20 days vaccination in 6 month old infants of the first group and the third group, and 8 month old infants of the second group, 18 (18/19,94.74%) monkeys of the first group and 3 (3/3,100%) monkeys of the third group produced antibody, The second group all could produce antibody. To 6 month, measles antibody of all infants is disappeared. The efficacy of immune in 8 month old infants is better than 6 month old infants, But the difference is not significant(P<0.05). Conclusion In order to decrease susceptible infants and prevent measles cases in infants before vaccination age(month).It was recommendated that the first measles vaccine in Macaca Fascicularis infants is 6 monthold.

Key words: Macaca Fascicularis, Measles, Maternal-transferred antibody, Vaccine

CLC Number:

Q95-33

DUO Hai-gang, SANG Chuan-lan, CHEN Zi-liang, LIANG Xing-lin, LI Bi-hai, Jin Shi-jun, RAO Jun-hua. The Antibody against Measles through Maternal-transferred and Immuno-response to First Measles Vaccine in Macaca fascicularis Infants[J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 347-350.

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