Laboratory Animal and Comparative Medicine ›› 2011, Vol. 31 ›› Issue (4): 273-275.DOI: 10.3969/j.issn.1674-5817.2011.04.010

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Protective Effects on Target-organ of Bu Yang Huan Wu Tang on SHR/SP

WU Yong-jie1, WU Zhuo-qun2, GU Wen-yong3, GE Jian3   

  1. 1. Shanghai Institute of Hypertension, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China;
    2. Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China;
    3. Ruijin Hospital,School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Received:2010-12-02 Online:2011-08-25 Published:2011-08-25

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Abstract: Objective To investigate whether Bu Yang Huan Wu Tang has any effect on target-organ protective effects of in stroke prone spontaneously hypertensive rats (SHR/SP), Methods Twenty male stroke-prone spontaneously hypertensive rats (SHR/SP) at 6 weeks-old were divided into 2 groups, one group rats were fed with Bu Yang Huan Wu Tang, another group rats were used as the control group. Meanwhile, 10 WKY rats with the same age were used as the normal blood pressure group.The test lasted for 3 months, the blood pressure, plasma NO, ET-1 content, rat heart, brain and kidney damage were observed. Results The damages of the target organs (heart, brain, kidney) in control group was significantly higher than treatment group and the WKY group (P<0.01). Blood pressure of the control group was significantly higher than treatment group (P<0.01) and WKY group (P<0.01). Plasma NO of control group was lower than treatment group (P<0.01). Plasma ET-1 of Control group was higher than treatment group (P<0.01). Conclusion Bu Yang Huan Wu Tang can reduce the SHR/SP blood pressure, reduce the SHR/SP target-organ (heart, brain, kidney) damage.

Key words: SHR/SP, Bu Yang Huan Wu Tang, Target-organ, Blood pressure, NO, ET-1

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