Analysis on Air Distribution by Computational Fluid Dynamics Simulation in Two Types of Laboratory Animal Barrier Facilities

doi:10.12300/j.issn.1674-5817.2021.077

Abstract

Abstract: Taking the removal efficiencies of waste heat, ammonia, and carbon dioxide, and the mean age of air as the evaluation indicators of air distribution, the pros and cons of air distribution in two different types of animal barriers, an experimental facility and a breeding facility, were analyzed at various air change rates and exhaust outlet positions by computational fluid dynamics (CFD) numerical simulation technology. The results of selected indicators showed that ceiling air supply plus bottom exhaust outlet were suitable for the laboratory animal barrier facilities. In addition, air change rate in high-density breeding facilities should be adjusted according to the room temperature.

Key words: Animal experiment, Animal breeding, Barrier facility, Removal efficiency, Mean age of air

CLC Number:

Q95-33

ZHOU Bin, ZHAO Yong, WANG Yabing, LIU Jihong. Analysis on Air Distribution by Computational Fluid Dynamics Simulation in Two Types of Laboratory Animal Barrier Facilities[J]. Laboratory Animal and Comparative Medicine, 2021, 41(3): 252-258.

Figures/Tables 12

References

[1] 中华人民共和国国家质量监督检验检疫总局, 中国国家标准化管理委员会. 实验动物环境及设施: GB 14925—2010[S]. 北京: 中国标准出版社, 2011.
[2] 中华人民共和国住房和城乡建设部, 中华人民共和国国家质量监督检验检疫总局. 实验动物设施建筑技术规范: GB 50447—2008[M]. 北京: 建筑工业出版社, 2008.
[3] 何婧. 大型实验动物房的环境控制[D]. 上海: 同济大学, 2003.
[4] 蒋新波. 基于CFD实验动物房气流环境系统的优化研究[D]. 衡阳: 南华大学, 2005.
[5] 杨五强, 潘杰, 李勋. 屏障系统回风口布置方式对气流组织的模拟分析[J]. 实验动物与比较医学, 2010, 30(5):384-387. DOI:10.3969/j.issn.1674-5817.2010.05.017.
[6] 朱颖心. 建筑环境学[M]. 北京: 中国建筑工业出版社, 2015.
[7] 毕波, 陈志鹏, 张聪, 等. 屏障环境设施指标动态变化的研究[J]. 实验动物科学, 2016, 33(6):55-58. DOI:10.3969/j.issn.1006-6179.2016.06.013.
[8] 张鑫, 李萌, 王金恒. 实验动物生产设施动态环境指标测定与数据分析[J]. 中国药事, 2012, 26(8):859-861. DOI:10.3969/j.issn.1002-7777.2012.08.018.
[9] 徐卫华. 小鼠呼出与吸入气体容量差值的测定[J]. 浙江大学学报(医学版), 2010, 39(3):322-325. DOI:10.3785/j.issn.1008-9292.2010.03.018.
[10] 孙泽, 罗明志, 陆云, 等. 小鼠呼气末CO₂分压快速检测方法及其在气道阻力评估中的应用研究[J]. 生物医学工程研究, 2016, 35(3):151-156.
[11] 沈永平, 王国亚. IPCC第一工作组第五次评估报告对全球气候变化认知的最新科学要点[J]. 冰川冻土, 2013, 35(5):1068-1076. DOI: 10.7522/j.issn.1000-0240.2013.0120.
[12] 赵彬, 李先庭, 彦启森. 用零方程湍流模型通风空调室内的空气流动[J]. 清华大学学报(自然科学版), 2001, 41(10):109-113. DOI:10.16511/j.cnki.qhdxxb.2001.10.030.
[13] 欧少华, 周斌, 刘吉宏. 某GLP实验动物设施空调及通风系统设计研究[J]. 中国比较医学杂志, 2020, 30(4):110-116. DOI:10.3969/j.issn.1671-7856.2020.04.017.

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