Safety Management Countermeasures Based on the Status of Laboratory Animal Administrative Licensing in Jiangsu Province

doi:10.12300/j.issn.1674-5817.2022.083

Abstract

Abstract:

With the rapid development of life science, laboratory animals play an important role in many fields, such as biomedicine. In recent years, the national reforms “to delegate power, streamline administration and optimize government services” continues deepen, the laboratory animals administrative departments have paid more attention to interim and post-event supervision, in which the safety management of laboratory animals is the key and challenging point in the supervision process. In this paper, the information regarding licenses for laboratory animals in Jiangsu, facility areas, animal production and usage, employees, and other information the past three years were introduced. Combined with legal administrative management in recent years, the potential safety risks in the production and use of laboratory animals were analyzed, such as risks in management systems, employees, facility operation, animal quality control, accidental injury and zoonosis, animal transportation, and waste disposal. Additionally, the current construction, daily management services, and the list of interim and post-event supervision of the laboratory animal safety management system were introduced. Based on this discussion, we proposed relevant safety management countermeasures and suggestions and provided support for further improvements to laboratory animal safety management.

Key words: Jiangsu Province, Laboratory animals, Risk and hidden danger, Safety management, Countermeasures

CLC Number:

Q95-33

Chongyang QI, Lin CHEN, Man AI, Hang XU, Housen ZHANG. Safety Management Countermeasures Based on the Status of Laboratory Animal Administrative Licensing in Jiangsu Province[J]. Laboratory Animal and Comparative Medicine, 2023, 43(1): 79-85.

Figures/Tables 2

References 11

1	李冠民, 邹大挺. 我国实验动物工作进展[J]. 实验动物科学与管理, 2001, 18(1):45-49. DOI:10.3969/j.issn.1006-6179.2001.01.015 .
	LI G M, ZOU D T. Progress in laboratory animal work in China[J]. Lab Anim Sci Adm, 2001, 18(1):45-49. DOI:10.3969/j.issn.1006-6179.2001.01.015 .
2	中华人民共和国科学技术部. 实验动物许可证管理办法(试行):国科发财字〔2001〕545号[A]. 2001.
	Ministry of Science and Technology of the People's Republic of China. Measures for the administration of laboratory animal licenses (for trial implementation): Guo Ke Fa Cai Zi〔2001〕No. 545[A. 2001.
3	江苏省人民政府. 江苏省实验动物管理办法: 省政府令第45号[A]. 2008.
	Jiangsu Provincial People's Government. The laboratory animal management measures of Jiangsu Province: provincial government order No. 45[A]. 2008.
4	杨艳红, 陈林, 张厚森, 等. 江苏省实验动物行政管理现状及对策[J]. 中国科技资源导刊, 2020, 52(3):37-40.
	YANG Y H, CHEN L, ZHANG H S, et al. Current situation and countermeasures of laboratory animal administration in Jiangsu Province[J]. China Sci Technol Resour Rev, 2020, 52(3):37-40.
5	陈林, 艾曼, 徐航, 等. 江苏省实验动物行政许可现状[J]. 实验动物与比较医学, 2021, 41(4):284-289.
	CHEN L, AI M, XU H, et al. Current status of administrative licensing for laboratory animals in Jiangsu Province[J]. Lab Anim Comp Med, 2021, 41(4):284-289.
6	彭华松, 徐汪节, 刘闯, 等. 国内高校实验动物安全管理的调查研究与思考[J]. 中国兽医学报, 2019, 39(3):598-602. DOI:10.16303/j.cnki.1005-4545.2019.03.37 .
	PENG H S, XU W J, LIU C, et al. Investigation and consideration of safety management for laboratory animals in Chinese universities[J]. Chin J Vet Sci, 2019, 39(3):598-602. DOI:10.16303/j.cnki.1005-4545.2019.03.37 .
7	刘丽艳, 韩艳梅, 李文超, 等. 实验动物潜在生物安全威胁及降低风险的建议[J]. 实验技术与管理, 2020, 37(2):264-266, 278. DOI:10.16791/j.cnki.sjg.2020.02.064 .
	LIU L Y, HAN Y M, LI W C, et al. Potential biosafety threats of laboratory animals and suggestions for risk reduction[J]. Exp Technol Manag, 2020, 37(2):264-266, 278. DOI:10.16791/j.cnki.sjg.2020.02.064 .
8	胡小林. 实验动物生物安全风险及管理对策[J]. 畜牧兽医科学(电子版), 2019(6):26-27. DOI:10.3969/j.issn.2096-3637.2019.06.015 .
	HU X L. Animal biological safety risks and management countermeasures[J]. Graziery Vet Sci Electron Version, 2019(6):26-27. DOI:10.3969/j.issn.2096-3637.2019.06.015 .
9	谢忠忱, 江轶, 黄开胜, 等. 高校实验动物生物安全管理模式研究[J]. 实验技术与管理, 2020, 37(2):1-5. DOI:10.16791/j.cnki.sjg.2020.02.001 .
	XIE Z C, JIANG Y, HUANG K S, et al. Research on laboratory animal biosafety management model in colleges and universities[J]. Exp Technol Manag, 2020, 37(2):1-5. DOI:10.16791/j.cnki.sjg.2020.02.001 .
10	江苏省科学技术厅. 加强实验动物行政许可事中事后监管工作的实施办法(修订版): 苏科技规〔2019〕330号[A/OL]. (2019-12-11)[2022-0601]..
	Jiangsu Provincial Department of Science and Technology. Implementation measures for strengthening operational and post-operational oversight of administrative license laboratory animals (revised version): Su Ke Ji Gui〔2019〕No. 330[Z]. (2019-12-11)[2022-0601].http://std.jiangsu.gov.cn/art/2019/12/11/art_82571_10218106.html..
11	魏强. 动物实验中的生物安全问题[J]. 中国比较医学杂志, 2015, 25(6):75-78. DOI:10.3969/j.issn.1671.7856.2015.006.019 .
	WEI Q. Biosafety issues in animal experiments in China[J]. Chin J Comp Med, 2015, 25(6):75-78. DOI:10.3969/j.issn.1671.7856.2015.006.019 .

物种 Species	实验动物生产量/万只 Production of laboratory animals/ten thousand			实验动物使用量/万只 Use of laboratory animals/ten thousand
物种 Species	2019	2020	2021	2019	2020	2021
小鼠Mouse	250.41	289.56	343.83	111.47	158.63	201.02
大鼠Rat	22.77	14.64	26.49	33.16	37.61	75.89
豚鼠Guinea pig	12.72	15.10	25.91	11.06	15.27	23.07
兔Rabbit	14.60	14.48	15.79	9.16	9.37	11.33
犬Dog	1.04	0.93	1.48	1.09	1.49	1.92
鸡Chicken	1.24	0.95	0.77	5.37	5.25	4.42
猪Swine	0.86	0.77	1.21	0.33	0.95	0.56
猴Monkey	0.31	0.27	0.24	1.05	1.23	1.89
雪貂Ferret	0.15	0.10	0.08	0.01	0.01	0.01
仓鼠Hamster	-	-	-	0.18	0.19	0.22
猫Cat	-	-	-	0.03	0.03	0.03
总数Total	304.10	336.80	415.80	172.91	230.03	320.36

物种 Species	实验动物生产量/万只 Production of laboratory animals/ten thousand			实验动物使用量/万只 Use of laboratory animals/ten thousand
物种 Species	2019	2020	2021	2019	2020	2021
小鼠Mouse	250.41	289.56	343.83	111.47	158.63	201.02
大鼠Rat	22.77	14.64	26.49	33.16	37.61	75.89
豚鼠Guinea pig	12.72	15.10	25.91	11.06	15.27	23.07
兔Rabbit	14.60	14.48	15.79	9.16	9.37	11.33
犬Dog	1.04	0.93	1.48	1.09	1.49	1.92
鸡Chicken	1.24	0.95	0.77	5.37	5.25	4.42
猪Swine	0.86	0.77	1.21	0.33	0.95	0.56
猴Monkey	0.31	0.27	0.24	1.05	1.23	1.89
雪貂Ferret	0.15	0.10	0.08	0.01	0.01	0.01
仓鼠Hamster	-	-	-	0.18	0.19	0.22
猫Cat	-	-	-	0.03	0.03	0.03
总数Total	304.10	336.80	415.80	172.91	230.03	320.36

[1]	Yong ZHAO. Evolution and Prospects of Laboratory Animal Management: A Case Study of Shanghai's Development in the Past Decade [J]. Laboratory Animal and Comparative Medicine, 2023, 43(5): 492-503.
[2]	Lianxiang GUO. Revision of Standards for Microbiological and Parasitological Grades in Laboratory Animals and Its Comparison to Foreign Standards [J]. Laboratory Animal and Comparative Medicine, 2023, 43(4): 339-346.
[3]	Huan GOU, Xinying AN, Yujia TONG, Yan WANG, Shuang YANG. Analysis on the Development Status of Laboratory Animals in Japan [J]. Laboratory Animal and Comparative Medicine, 2023, 43(2): 194-204.
[4]	Xiaying LI, Yusheng WEI, Yonglu TIAN, Wanyong PANG. A Brief Interpretation of CCAC Guide on Humane Endpoints of Animals: 2022 Edition [J]. Laboratory Animal and Comparative Medicine, 2022, 42(6): 566-571.
[5]	Jian WANG, Jin LU, Lingyun TAO, Hongkun FU, Cheng GAO, Baojin WU, Yao LI, Yufeng TAO. Analysis on the Standardized Expression of the Accredited Ability Scope for Hematology, Blood Biochemistry and Urinalysis in Laboratory Animal Clinical Testing [J]. Laboratory Animal and Comparative Medicine, 2022, 42(6): 511-517.
[6]	Huiping LI, Chujun LIANG, Weibo ZHAO. The Current Status of Laboratory Animal License Administration in Guangdong Province [J]. Laboratory Animal and Comparative Medicine, 2022, 42(6): 577-582.
[7]	Xiuqing ZHENG, Zhiqiang SHAO, Jing SONG, Yuehua ZHANG, Jinhua SU. Practice of ABSL-2 Laboratory Process Management in Universities： Xiamen University as An Example [J]. Laboratory Animal and Comparative Medicine, 2022, 42(4): 364-370.
[8]	Wei ZHANG, Bin TANG, Yong ZHAO, Zhini ZHANG, Xinyan DENG. Tracking and Monitoring on Application of Micro-electrolyzed Sterile Water System in Laboratory Animal Barrier Facilities [J]. Laboratory Animal and Comparative Medicine, 2022, 42(2): 117-121.
[9]	Yuqin YANG. Biosafety Problems and Countermeasures in the Management of Barrier Facilities for Laboratory Animals [J]. Laboratory Animal and Comparative Medicine, 2022, 42(2): 95-101.
[10]	HAN Yuanyuan, LI Na, DAI Jiejie. History and Countermeasure Discovered from 40-year Development of Laboratory Animals in Yunnan Province [J]. Laboratory Animal and Comparative Medicine, 2021, 41(5): 399-408.
[11]	SONG Guoying, XU Yan, ZHU Meilin, ZHANG Hongwei, LI Pei. Practice and Exploration of Laboratory Animal and Laboratory Safety Training for Medical Freshmen [J]. Laboratory Animal and Comparative Medicine, 2021, 41(5): 450-454.
[12]	LIU Xiaonan, ZHANG Wei, MENG Xia, LU Jing. Design and Application of an Online Centralized Procurement System for Laboratory Animals in Universities: Capital Medical University as an Example [J]. Laboratory Animal and Comparative Medicine, 2021, 41(5): 459-465.
[13]	CHEN Lin, AI Man, XU Hang, QI Chongyang, SHI Aimin. Current Status of Administrative Licensing for Laboratory Animals in Jiangsu Province [J]. Laboratory Animal and Comparative Medicine, 2021, 41(4): 284-289.
[14]	ZHANG Ruihu, WANG Chunfang, SONG Guohua, CHEN Zhaoyang. Status and Development Countermeasures of Laboratory Animal Resource Sharing Service Platform Construction in Shanxi Province [J]. Laboratory Animal and Comparative Medicine, 2021, 41(3): 190-194.
[15]	JIANG Kun, TANG Yiwen, LIU Yanbin, CHEN Liming, TANG Hongbin. Design of Health Code Management Framework for Laboratory Animals [J]. Laboratory Animal and Comparative Medicine, 2021, 41(1): 66-69.