
实验动物与比较医学 ›› 2025, Vol. 45 ›› Issue (2): 247-250.DOI: 10.12300/j.issn.1674-5817.2025.025
• 科普讲坛 • 上一篇
孙强
收稿日期:2025-02-24
修回日期:2025-04-23
出版日期:2025-04-25
发布日期:2025-04-25
作者简介:
Received:2025-02-24
Revised:2025-04-23
Published:2025-04-25
Online:2025-04-25
中图分类号:
孙强. 动物实验中性别“歧视”的危害与反思[J]. 实验动物与比较医学, 2025, 45(2): 247-250. DOI: 10.12300/j.issn.1674-5817.2025.025.
| 1 | 孙强. 为什么要开展动物实验[J]. 实验动物与比较医学, 2024, 44(1): 121-126. DOI:10.12300/j.issn.1674-5817.2023.177 . |
| 2 | 孙强. 如果动物实验不严谨[J]. 实验动物与比较医学, 2024, 44(2): 234-237. DOI:10.12300/j.issn.1674-5817.2024.039 . |
| 3 | CLAYTON J A, COLLINS F S. Policy: NIH to balance sex in cell and animal studies[J]. Nature, 2014, 509(7500):282-283. DOI:10.1038/509282a . |
| 4 | BEERY A K, ZUCKER I. Sex bias in neuroscience and biomedical research[J]. Neurosci Biobehav Rev, 2011, 35(3):565-572. DOI:10.1016/j.neubiorev.2010.07.002 . |
| 5 | WOITOWICH N C, BEERY A, WOODRUFF T. A 10-year follow-up study of sex inclusion in the biological sciences[J]. eLife, 2020, 9: e56344. DOI:10.7554/eLife.56344 . |
| 6 | PRENDERGAST B J, ONISHI K G, ZUCKER I. Female mice liberated for inclusion in neuroscience and biomedical research[J]. Neurosci Biobehav Rev, 2014, 40:1-5. DOI:10.1016/j.neubiorev.2014.01.001 . |
| 7 | BEERY A K. Inclusion of females does not increase variability in rodent research studies[J]. Curr Opin Behav Sci, 2018, 23:143-149. DOI:10.1016/j.cobeha.2018.06.016 . |
| 8 | COLLINS F S, TABAK L A. Policy: NIH plans to enhance reproducibility[J]. Nature, 2014, 505(7485):612-613. DOI:10.1038/505612a . |
| 9 | HEALTH-CANADA. Health portfolio sex - and gender-based analysis plus policy: advancing equity, diversity and inclusion [EB/OL]. (2023-01-27)[2025-02-25]. https://www.canada.ca/en/health-canada/corporate/transparency/heath-portfolio-sex-gender-based-analysis-policy.html. |
| 10 | National Institutes of Health. Consideration of sex as a biological variable in NIH-funded research[EB/OL]. (2015-06-19)[2025-02-25]. https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-102.html. |
| 11 | Cleveland Clinic. Early warning signs of a heart attack[EB/OL]. (2024-09-16)[2025-02-25]. https://health.clevelandclinic.org/early-signs-of-a-heart-attack. |
| 12 | SKELLY D A, SQUIERS G T, MCLELLAN M A, et al. Single-cell transcriptional profiling reveals cellular diversity and intercommunication in the mouse heart[J]. Cell Rep, 2018, 22(3):600-610. DOI:10.1016/j.celrep.2017.12.072 . |
| 13 | KLEIN S L, FLANAGAN K L. Sex differences in immune responses[J]. Nat Rev Immunol, 2016, 16(10):626-638. DOI:10.1038/nri.2016.90 . |
| 14 | FAIRWEATHER D, ROSE N R. Women and autoimmune diseases[J]. Emerg Infect Dis, 2004, 10(11):2005-2011. DOI:10.3201/eid1011.040367 . |
| 15 | DUBOIS E L, HOROWITZ R E, DEMOPOULOS H B, et al. NZB/NZW mice as a model of systemic lupus erythematosus[J]. JAMA, 1966, 195(4):285-289. DOI:10.1001/jama. 1966. 03100040091025 . |
| 16 | HENDRIKSEN L C, VAN DER LINDEN P D, LAGRO-JANSSEN A L M, et al. Sex differences associated with adverse drug reactions resulting in hospital admissions[J]. Biol Sex Differ, 2021, 12(1):34. DOI:10.1186/s13293-021-00377-0 . |
| 17 | ZHAO H, DIMARCO M, ICHIKAWA K, et al. Making a 'sex-difference fact': ambien dosing at the interface of policy, regulation, women's health, and biology[J]. Soc Stud Sci, 2023, 53(4):475-494. DOI:10.1177/03063127231168371 . |
| 18 | Food and Drug Administration. FDA Drug Safety Communication: FDA approves new label changes and dosing for zolpidem products and a recommendation to avoid driving the day after using Ambien CR[EB/OL]. (2013-05-14)[2025-02-25]. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-approves-new-label-changes-and-dosing-zolpidem-products-and. |
| 19 | RIDKER P N, COOK N R, LEE I M. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women[J]. J Vasc Surg, 2005, 42(1):179. DOI:10.1016/j.jvs.2005.04.009 . |
| 20 | ROSANO G M C, LEWIS B, AGEWALL S, et al. Gender differences in the effect of cardiovascular drugs: a position document of the Working Group on Pharmacology and Drug Therapy of the ESC[J]. Eur Heart J, 2015, 36(40):2677-2680. DOI:10.1093/eurheartj/ehv161 . |
| 21 | KARP N A, MASON J, BEAUDET A L, et al. Prevalence of sexual dimorphism in mammalian phenotypic traits[J]. Nat Commun, 2017, 8:15475. DOI:10.1038/ncomms15475 . |
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