导管术致新西兰兔充血性心衰的心气虚模型研究

doi:10.3969/j.issn.1674-5817.2012.03.006

实验动物与比较医学 ›› 2012, Vol. 32 ›› Issue (3): 199-202.DOI: 10.3969/j.issn.1674-5817.2012.03.006

导管术致新西兰兔充血性心衰的心气虚模型研究

王萧¹, 董浩然¹, 林传权¹, 许庆文²

广州中医药大学1.实验动物中心;
2.临床药理研究所, 广州 510405

收稿日期:2011-08-15 出版日期:2012-06-25 发布日期:2012-06-25
作者简介:王萧(1972-), 男, 博士, 研究员, 从事人类疾病动物模型研究。E-mail: xwang72@163.com
基金资助:
广东省自然科学基金项目(815104701000001)

Catheterization Caused Congestive Heart Failure Rabbit Model of Heart Qi deficiency

WANG Xiao¹, DONG Hao-ran¹, LIN Chuan-quan¹, XU Qing-wen²

1. Laboratory Animal Center,
2. Institute of Clinical Pharmacology,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405, China

Received:2011-08-15 Online:2012-06-25 Published:2012-06-25

摘要/Abstract

摘要： 目的运用导管术构建新西兰兔充血性心衰的心气虚模型。方法运用导管术造成兔的超容量负荷型心衰模型,造模后15 d和30 d从动物的一般状态、饲料消耗指数、体重增加指数、心率、呼吸频率和心电图等指标进行量化观察。结果与正常对照组比较,SBP、DBP和LVSP等血流动力学指标显著性下降,造模后15 d、30 d家兔活动明显减少、精神萎靡、抓起反抗力度减轻,饲料消耗指数与体重增加指数降低,呼吸频率和心率明显增加,且心电图出现异常Q波、ST段抬高。结论以动物的一般状态、心率、呼吸频率、心电图表现、饲料消耗指数和体重增加指数等指标基本可以定性定量地反映出充血性心衰的心气虚模型特征。

关键词: 充血性心衰, 心气虚, 兔模型

Abstract: Objective To construct congestive heart failure rabbit model of heart Qi deficiency caused by catheterization. Methods Construct cardiac hyper-volume overload, rabbit heart failure model was caused by catheterization.Fifteen and 30 days after modeling, the general status, feed consumption index, body weight index, heart rate, respiration and ECG were observed and measured. Results Compared with the normal control group, SBP, DBP, LVSP and other hemodynamic index decreased significantly. After 15 and 30 days of modeling, the activity of model's rabbit was significantly reduced, the apathetic, efforts of resisting grab were reduced, feed consumption and body weight indices were decreased, breathing and heart rate were increased significantly, abnormal Q wave was appeared, and ST wave segment was elevated. Conclusion The heart rate, respiration, ECG, body weight and feed consumption index and other indicators can qualitatively and quantitatively reflect the heart failure model of heart qi deficiency.

Key words: Congestive heart failure, Heart qi deficiency, Rabbit, Model

中图分类号:

Q95-33

王萧, 董浩然, 林传权, 许庆文. 导管术致新西兰兔充血性心衰的心气虚模型研究[J]. 实验动物与比较医学, 2012, 32(3): 199-202.

WANG Xiao, DONG Hao-ran, LIN Chuan-quan, XU Qing-wen. Catheterization Caused Congestive Heart Failure Rabbit Model of Heart Qi deficiency[J]. Laboratory Animal and Comparative Medicine, 2012, 32(3): 199-202.

[1]	孙立旦, 杨飞霞, 张迪, 陈泽良, 张志慧, 李英俊, 史利军. 国产猪小肠黏膜下层脱细胞基质用于兔硬脑膜修复的效果及安全性[J]. 实验动物与比较医学, 2022, 42(1): 36-41.
[2]	丰华，程明军，徐丛剑. 家兔宫颈注射荧光纳米颗粒盆腔淋巴结聚集性的实验观察[J]. , 2010, 30(3): 180-182.

导管术致新西兰兔充血性心衰的心气虚模型研究

Catheterization Caused Congestive Heart Failure Rabbit Model of Heart Qi deficiency

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 2

编辑推荐

Metrics

本文评价