柴油机排放颗粒物有机组分的致突变试验

实验动物与比较医学 ›› 1997, Vol. 17 ›› Issue (4): 210-212.

柴油机排放颗粒物有机组分的致突变试验

1.中国生育调节药物毒理检测中心，上海 20032；2.上海医科大学环境卫生教研室

收稿日期:1997-03-31 出版日期:1997-01-25 发布日期:2013-03-19
基金资助:
国家自然科学基金

Mutagenicity Test of Various Fractions of Diesel Exhaust Particulates in Vivo and in Vitro

1.National Evaluation Centre for the Toxicology of Fertility Regulating Drugs，Shanghai 200032；2.Shanghai Medical University

Received:1997-03-31 Published:1997-01-25 Online:2013-03-19

摘要/Abstract

摘要： 采用小鼠骨髓嗜多染红细胞（PCE）及体外培养中国仓鼠卵巢（CHO）细胞，对国产跃进牌中型柴油机排放颗粒物的不同有机组分进行体内及体外微核试验。结果表明：各组分均能引起体内PCE及体外培养CHO细胞微核率的增加，且在一定剂量（浓度）范围内微核率随剂量（浓度）增加而增加，各组分中以有机碱、多环芳烃和极性化合物的致突变性较强。

关键词: 柴油机, 排放颗粒物, 有机组分, 微核试验

Abstract: "The mutagenicities of the various organic fractions of the exhaust particulates from the diesel (trademark : Yuejin) were studied by micronucleus test on bone marrow polychromatid erythrocytes (PCE,in vivo) in mice and Chinese hamster ovarian cells (CHO in vitro). The results showed that all the five fractions of the diesel exhaust particulates could significantly increase the frequencies of micronucleus of PCE and CHO，in comparison with DMSO control (P＜0.05 or P＜0.01),and the dose - response relationships were apparent. The mutagenicities of organic bases，polycyclic aromatic hydrocarbons and polar compounds were higher than those of the other fractions. "

Key words: "Diesel exhaust particulate, Organic fraction, Frequency of micronucleus, Mouse, Chinese hamster ovarian cell "

吕元明1,丁训诚1,叶舜华2. 柴油机排放颗粒物有机组分的致突变试验[J]. 实验动物与比较医学, 1997, 17(4): 210-212.

吕Yuan-Ming-1,DING Xun-Cheng-1,YE Shun-Hua-2. Mutagenicity Test of Various Fractions of Diesel Exhaust Particulates in Vivo and in Vitro[J]. Laboratory Animal and Comparative Medicine, 1997, 17(4): 210-212.

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