Application of Cynomolgus Monkey in Medical Science

doi:10.3969/j.issn.1674-5817.2012.04.023

Abstract

Abstract: Cynomolgus monkey is one species of non-human primates, whose structure of tissues, immunity, physiology and metabolism are very similar to those of human, so they have been the most important and ideal experimental animals. In this paper, recent progress and their applications in biomedical research such as nervous system, reproductive system, stem cells, malignant diseases and diabetes are mainly reviewed.

Key words: Cynomolgus monkey, Nervous system, Reproductive system, Stem cells

CLC Number:

Q95-33

SHI Qiao-juan,LI wei,SA Xiao-ying. Application of Cynomolgus Monkey in Medical Science[J]. Laboratory Animal and Comparative Medicine, 2012, 32(4): 358-365. DOI: 10.3969/j.issn.1674-5817.2012.04.023.

References

[1] Huh JW, Kim YH, Park SJ, et al.Large-scale transcriptome sequencing and gene analyses in the crab-eating macaque (macaca fascicularis) for biomedical research[J]. BMC Genomics, 2012, 13(1):163.
[2] Ebeling M, Küng E, See A, et al.Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment[J]. Genome Res, 2011, 21(10):1746-56.
[3] 朱华, 李秦, 徐艳峰, 等. 光化学法制作食蟹猴局部脑缺血模型[J]. 中国比较医学杂志, 2008, 18(9):32-35.
[4] 李加美, 朱华, 刘颖, 等. IL210 在人骨髓间充质干细胞移植治疗食蟹猴脑缺血中的作用[J]. 中国比较医学杂志,2009, 19(12):1-5.
[5] 韦日明, 冯飞玲, 黄志宏, 等. 局部脑缺血食蟹猴动物模型的建立[J]. 广西医科大学学报, 2006, 23(2):456-458.
[6] 朱华, 李秦, 冯铭, 等. 食蟹猴脑出血模型的建立及评价[J]. 中国比较医学杂志, 2009, 19(7):29-33.
[7] Bons N, Mestre N, Ritchie K, et al.Identification of amyloid beta protein in the brain of the small, short-lived lemurian primate Microcebus murinus[J]. Neurobio of Aging, 1994, 15(2):215-220.
[8] Kimura N, Okabayashi S, Ono F.Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function[J]. Am J Pathol, 2012, 180(2):550-561.
[9] Bihaqi SW, Huang H, Wu J, et al.Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease[J]. J Alzheimers Dis, 2011, 27(4):819-33.
[10] Massacesi L, Joshi N, Lee-Parritz D, et al.Experimental allergic encephalomyelitis in cynomolgus monkeys. Quantitation of T cell responses in peripheral blood[J]. J Clin Invest, 1992, 90(2):399-404.
[11] 孙晓梅, 陈瑜, 李春花, 等. 食蟹猴少精弱精动物模型建立的研究[J].实验动物科学与管理, 2006, 23(2):22-25.
[12] Guo J, Jia Y, Tao SX, et al.Expression of nitric oxide synthase during germ cell apoptosis in testis ofcynomolgus monkey after testosterone and heat treatment[J]. J Androl, 2009, 30(2):190-199.
[13] Li X, Liu Q, Liu S, Zhang X, et al.The spatiotemporal expression changes of 16 epididymis-specific genes induced by testosterone, heat, and combination treatment in cynomolgus monkey[J]. Acta Biochim Biophys Sin (Shanghai),2008, 40(8):721-728.
[14] Haruyama E, Ayukawa Y, Kamura K, et al. Morphometric examination for development of reproductive organs in male cynomolgus monkeys[J]. Toxicol Pathol, 2012, May 2[Epub ahead of print].
[15] van Alphen MMA, van de Kant HJG, de Rooij DG. Protection from radiation-induced damage of spermatogenesis in the rhesus monkey (Macaca mulatta)by follicle-stimulating hormone[J].Cancer Res, 1989, 49:533-536.
[16] Liang JH, Sankai T, Yoshida T, et al.Immunolocalization of proliferating cell nuclear antigen (PCNA) in cynomolgusmonkey (Macaca fascicularis) testes during postnatal development[J]. J Med Primatol, 2001, 30(2):107-111.
[17] 马南花, 黎宗强, 覃坚, 等. 雌性食蟹猴月经周期中血清雌激素、孕激素水平的变化[J]. 实验动物与比较医学, 2008, 28(2):106-109.
[18] 佟巍, 丛喆, 蒋红, 等. SIV mac感染食蟹猴、猕猴的外周血血象观察[J]. 实验动物科学与管理, 2002, 19(4):17-20.
[19] Negri DR, Borghi M, Baroncelli S, et al.Identification of a cytotoxic T-lymphocyte (CTL) epitope recognized byGag-specific CTLs in cynomolgus monkeys infected with simian/human immunodeficiency virus[J]. J Gen Virol, 2006, 87(Pt 11):3385-3392.
[20] de Groot NG, Heijmans CM, Koopman G, et al. TRIM5 allelic polymorphism in macaque species/populations of different geographic origins: its impact on SIV vaccine studies[J]. Tissue Antigens, 2011, 78(4):256-262.
[21] McAuliffe J, Vogel L, Roberts A, et al. Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys[J]. Virology,2004, 330(1):8-15.
[22] Smits SL, van den Brand JM, de Lang A, et al. Distinct severe acute respiratory syndrome coronavirus-induced acute lung injury pathways in two different nonhuman primate species[J]. J Virol, 2011, 85(9):4234-4245.
[23] 魏强, 高虹, 蒋虹, 等. SARS恢复猴和灭活疫苗免疫实验猴再次感染SARS-CoV研究[J]. 中国比较医学杂志, 2006,16(11):641-646.
[24] Kuiken T, Rimmelzwaan GF, Van Amerongen G, et al.Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis)[J]. Vet Pathol,2003, 40(3):304-310.
[25] 李加美, 陈云新, 朱华, 等. 禽流感病毒感染食蟹猴肺组织内抗原提呈细胞亚型分析[J]. 中国比较医学, 2008, 18(8):1-5.
[26] Tolnay AE, Baskin CR, Tumpey TM, et al.Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus[J]. Arch Virol, 2010, 155(6):905-914.
[27] Ichinohe T, Ainai A, Ami Y, et al.Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus[J]. J Med Virol, 2010, 82(10):1754-1761.
[28] Toyoshima Y, Sekiguchi S, Negishi T, et al.Differentiation of neural cells in the fetal cerebral cortex of cynomolgus monkeys (Macaca fascicularis). Comp Med, 2012, 62(1):53-60.
[29] Yue F, Chen B, Wu D, et al.Biological properties of neural progenitor cells isolated from the hippocampus of adult cynomolgus monkeys[J]. Chin Med J (Engl), 2006, 119(2): 110-116.
[30] Wang P, Liu XM, Liu XM, et al.Isolation, characterization andgene modification of fetal neural stem/progenitor cells from cynomolgus monkey[J]. Neuroreport, 2008, 19(4): 419-424.
[31] Li W, Liu C, Qin J, Zhang L, et al.Efficient genetic modification of cynomolgus monkey embryonic stem cells with lentiviral vectors[J]. Cell Transplant, 2010, 19(9):1181-1193.
[32] Ueda S, Yoshikawa M, Ouji Y, et al.Cynomolgus monkey embryonic stem cell lines express green fluorescent protein[J]. J Biosci Bioeng, 2006, 102(1):14-20.
[33] Ooto S, Haruta M, Honda Y, et al.Induction of the differentiation of lentoids from primate embryonic stem cells[J].Invest Ophthalmol Vis Sci, 2003, 44(6):2689-2693.
[34] Muramatsu S, Okuno T, Suzuki Y, et al.Multitracer assessment of dopamine function after transplantation of embryonic?stem cell-derived neural stem cells in a primate model of Parkinson's disease[J]. Synapse, 2009, 63(7):541-548.
[35] Okahara-Narita J, Umeda R, Nakamura S, et al.Induction of pluripotent stem cells from fetal and adult cynomolgus monkey fibroblasts using four human transcription factors[J]. Primates, 2012, 53(2):205-213.
[36] Ren Z H, Wang J Y, Zou C L, et al.Comparative characterization of mesenchymal stem cells from different age groups of cynomolgus monkey[J]. Sci China Life Sci, 2010, doi: 10.1007/s11427-010-0083-7
[37] Jiang X, Xu R, Yang Z, et al.Experimental study on trace marking and oncogenicity of neural stem cells derived from bone marrow[J]. Cell Mol Neurobiol, 2008, 28(5):689-711.
[38] 刘嘉琳, 李加美, 朱华, 等. 人骨髓间充质干细胞移植对食蟹猴脑出血模型损伤的修复作用[J]. 中国比较医学杂志,2009, 19(10):1-5.
[39] Litwak KN, Cefalu WT, Wagner JD.Chronic hyperglycemia increases arterial low-density lipoprotein metabolism and atherosclerosis in cynomolgus monkeys[J]. Metabolism,1998, 47(8):947-954.
[40] Koulmanda M,Qipo A, Chebrolu S, et al.The efect of low versus high dose of streptozotocin in cynomolgus monkeys(Macaca fascilularis)[J]. Am J Transplant, 2003, 3(3):267-272.
[41] Wu D, Zou C, Yue F, et al.The effect of long-term streptozotocin-induced diabetes mellitus(STZ-DM) on cynomolgus (Macaca fascicularis)monkeys[J]. J Med Primatol, 2009, 38(1):15-22.
[42] Wagner JE, Kavanagh K, Ward GM, et al.Old world nonhuman primate models of type 2 diabetes mellitus[J]. ILAR J,2006, 47(3):259-271.
[43] 靳丽莎, 郝香芬, 彭白露, 等. 六个肥胖相关基因在食蟹猴2型糖尿病不同发病时期的差异表达[J]. 动物学研究,2011, 32(1):50-55.
[44] Bagdade JD, Wagner JD, Rudel LL, et al.Accelerated cholesteryl ester transfer and altered lipoprotein composition in diabetic cynomolgus monkeys[J]. J Lipid Res, 1995, 36(4):759-766.
[45] Wieczorek G, Bigand M, Menninger K, et al.Acute and chronic vascular rejection in nonhuman primate kidney transplantation.[J]. Am J Transplant, 2006, 6(6):1285-1296.
[46] Aoyagi T, Yamashita K, Suzuki T, et al.A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus?monkeys: induction and maintenance therapy[J]. Am J Transplant, 2009, 9(8):1732-1741.
[47] Bigaud M, Wieczorek G, Beerli C, et al.Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts[J]. Transplantation, 2012,93(2):156-164.
[48] Jacobson LH, Commerford SR, Gerber SP, et al.Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity[J]. Naunyn Schmiedebergs Arch Pharmacol, 2011, 384(6):565-581.
[49] Warncke M, Calzascia T, Coulot M, et al.Different adaptations of IgG effector function in human and nonhuman primates and implications for therapeutic antibody treatment[J]. J Immunol, 2012, 188(9):4405-4411.
[50] Uno Y, Osada N.CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2[J]. BMC Evol Biol, 2011,11:283.
[51] Uehara S, Murayama N, Nakanishi Y, et al.Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys[J]. J Pharmacol Exp Ther, 2011,339(2):654-661.