Chronic Restraint Stress Induced Anxiety- and Depression-like Behaviors in Spontaneously Hypertensive Rats

doi:10.3969/j.issn.1674-5817.2014.02.003

Abstract

Abstract: Objective To investigate the effects of chronic restraint stress (CRS) on anxiety- and depression-like behaviors in Spontaneously Hypertensive Rats(SHR). Methods SHR were randomly divided into control(CON) group and CRS group respectively. The changes of behaviors were detected by open field test (OFT),forced swimming test (FST) and elevated plus maze(EPM) testŁ¬the changes of blood pressure and levels of adrenocorticotropic hormone(ACTH) in plasma in different groups were also measured and compared. Results SHR in CRS group showed significant reductions in rearing incidence in OFT(PŁĽ0.05),the time spent in open arms during the EPM(PŁĽ0.05), and the immobility during the FST was increased significantly (PŁĽ0.05). Furthermore, the blood pressure and concentration of plasma ACTH increased significantly in CRS group compared to CON group. Conclusions CRS can induce anxiety- and depression-like behaviors in SHR.

Key words: Spontaneously Hypertensive Rat(SHR), Chronic Restraint Stress(CRS), Depression, Anxiety

CLC Number:

Q95-33

CAO Shuang, DING Jian-wei, LI Bing, YUAN Li-fen, DU Qin. Chronic Restraint Stress Induced Anxiety- and Depression-like Behaviors in Spontaneously Hypertensive Rats[J]. Laboratory Animal and Comparative Medicine, 2014, 34(2): 93-97.

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