Abstract: Objective To study the heart protective effect of 1,25(OH)₂D₃ on diabetic NOD mice Methods A total of 19 NOD mice were enrolled in the study, all of them were treated to be the model of diabetes by injecting CTX, and then randomly divided into 1.25(OH)₂D₃ group and untreated group.Other 4 BALB/c mice were set as normal controls. Myocardial morphology was observed in all three groups after 4 weeks. Results The Electronic microscopic findings showed that after the treatment of four weeks with 1.25(OH)₂D₃, the heart pathological changes were markedly reduced as compared with those diabetic mice untreated by 1.25(OH)₂D₃. Conclusion Treatment with 1.25(OH)₂D₃ can reduce the injury of the heart and prevent the pathological progress of structure of heart in NOD mice.

Key words: Diabetic, NOD, 1,25(OH)₂D₃