Abstract: Objective To observe the acute toxicity of melamine and the detoxification of San Jin Tang in Kunming (KM) mice. Methods Ninety SPF KM mice (half male and female) were divided into seven groups administered with different dosage of melamine and two blank control groups. The toxic reaction to the mice caused by melamine was observed, and 70 SPF KM mice were divided into high,middle and low dosage of San Jin Tang(三金汤）administered preventive groups,San Jin Tang treatment group，melamine model group and two control groups. The detoxification of San Jin Tang in kindey and lungs after of mice administered with melamine one time was observed. Results The LD₅₀ of melamine to KM mice was 9366 mg/kg. There were no crystallization in kidney but inflammatory cells infiltration appeared m kidney, liver and lung. The content of melamine in kidneys and lung was 327ng/g and 177.5 ng/g respectively. The high dosage of San Jin Tang had best effects on cleaning up the melamine in kidney and lung, reduced to 58 ng/g and 28.2 ng/g, respectively. Conclusion The preliminary experi-ments suggested that the melamine was micro-toxic or non-toxic. The higher dose group of Chinese Medicine San Jin Tang showed best effect to get rid of melamine in mice.

Key words: Melamine, Mice, Acute toxicity, Chinese crude drug, San Jin Tang(三金汤）