Effect of Aging and Stress on the Ultrastructure of Nucleus Pulposus in Rat

Abstract

Abstract: The bipedal rats model was developed by forelimb amputation and special rearing methodvs.Normal rats served as the control. The ultrastructure of nucleus pulposus of L2-3 discs of these rats were observed under electron microscope. With the increasing of aging and stress, obvious degeneration and necrosis were observed in the notochordal cells in nucleus pulposus of SD rats. In the matrix the arrangement of the collagen fiber became disordered, lamellar structures and mass appeared. These results demonstrated that aging and stress accelerated the degeneration of nucleus pulposus of SD rats. The degeneration proce-dure was in agreement with that of human beings.

Key words: Intervertebral disc, Degeneration, Ultrastructure, Bipedal rat

WU Jing-ping1,CHEN Tong-yi2,CHEN Zhong-wei2，Shen Qiang3. Effect of Aging and Stress on the Ultrastructure of Nucleus Pulposus in Rat[J]. , 2003, 23(4): 197-199.

[1]	ZHAO Yupeng, ZHOU Pinghui, GUAN Jianzhong. Comparison of Different Slicing and Staining Methods of Caudal Intervertebral Discs in Rats [J]. Laboratory Animal and Comparative Medicine, 2021, 41(2): 100-107.
[2]	QIAO Ming, YANG Zheng-ming, HUANG Qian, LIU Lan-ying. Effect of Acupoint Sticking Therapy on Eosinophils and Ultrastructure of Lung Tissue in Asthmatic Rats [J]. Laboratory Animal and Comparative Medicine, 2016, 36(4): 276-279.
[3]	YUAN Zi-yan, ZHAO Yi-ning, ZHANG Lu, ZHAO Shan-min, LIN Li-fang, TANG Qiu, Sun Wei, YU Chen-ling, CAI Li-ping, XU Chen, CUI Shu-fang. Observation on Microstructure and Ultrastructure of Liver in Naked Mole Rat [J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 373-377.
[4]	YUAN Zi-yan, ZHAO Yi-ning, ZHANG Lu, ZHAO Shan-min, LIN Li-fang, TANG Qiu, Sun Wei, YU Chen-ling, CAI Li-ping, XU Chen, CUI Shu-fang. Observation on Micro- and Ultra-structures of the Lung in Naked Mole Rar (Heterocephalus glaber) [J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 378-382.
[5]	YUAN Zi-yan, ZHAO Yi-ning, ZHANG Lu, ZHAO Shan-min, LIN Li-fang, TANG Qiu, Sun Wei, YU Chen-ling, CAI Li-ping, XU Chen, CUI Shu-fang. Observation on Micro- and Ultra-structures of Heart in Naked Mole Rat (Heterocephalus glaber) [J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 383-387.
[6]	ZHANG Lu, ZHAO Yi-ning, YUAN Zi-yan, ZHAO Shan-min, LIN Li-fang, TANG Qiu, Sun Wei, YU Chen-ling, CAI Li-ping, XU Chen, CUI Shu-fang. Comparison on Micro- and Ultrastructure of Kidney between Naked Mole Rats and C57BL/6J Mice [J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 388-394.
[7]	ZHAO Shan-min, ZHAO Yi-ning, TANG Qiu, ZHANG Lu, YUAN Zi-yan, LIN Li-fang, XU Chen, CAI Li-ping, SUN Wei, CUI Shu-fang. Anatomical and Histological Characteristics, and Ultrastructure of Thymus, Spleen and Lymph Node in Naked Mole Rat [J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 395-399.
[8]	SHI Yong, WANG Zi-wei, SONG Xiang-fu, SUN Bing-xue. The Effect of Zinc on Content of Metallothionein and Ultrastructure in Liver and Brain of Rats Injected with Methylmercury [J]. Laboratory Animal and Comparative Medicine, 2011, 31(4): 252-254.
[9]	CHU Xiao-hong1, PU Jun-yi1,2,3, BAO Hui-jun1, HU Jian-hua2,GAO Cheng2, YAO Yi-lin1，XU Chun-sheng1，QIN Jun-hui1, CHENG Qiu-sheng1. Observation on Micro- and Ultra-structures of the Liver in Zebrafish(Brachydanio rerio) [J]. , 2010, 30(1): 17-23.
[10]	WU Shu-yan1, GU Tao2, ZHOU Huan2, WANG Xiang-ying1,LI Su-an1, MAO Di-hua1, ZHANG Xue-guang2. Ultrastructure of Murine Bone Marrow-derived Dendritic Cells [J]. , 2004, 24(1): 34-36.
[11]	DAI Hao-liang,Chen Yi-ping, Zhang Gai, Liu Geng, Wan Wei-chang. Study on the Lingual Ultrastructure and Pathological Coating Model in Miniature Pig [J]. , 2003, 23(1): 10-11.
[12]	HU Jian-shi，WENG Jing-lin，ZHENG Zhi-liong. Culture, Cryopreservation and Recovery of Adult Buffalo Lens Epithelial Cells [J]. , 2002, 22(4): 223-226.
[13]	LUO Hui-juan，WANG Zi-neng，MENG Rui-lin, GONG Hua-fang. The Effects of Mifepristone on the Cerebral Tissue of Term Pregnant Rats [J]. , 2001, 21(2): 85-87.
[14]	Yin Song-lin1;Li Qing-pei1;Wang Wei-wen2. The Effect of Extracorporeal Shockwave on Ultrastructure of the Main Internal Organs and Serum Biochemistry in Dogs [J]. , 1993, 13(4): 197-199.
[15]	Cai Yu-wen et al. The Ultrastructural Location of the ATPase and G-6-Pase in Lymphocytes of the Lymph Nodes in Rhesus Monkey [J]. , 1993, 13(4): 206-207.

Effect of Aging and Stress on the Ultrastructure of Nucleus Pulposus in Rat

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments